ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Research Centers: Recent submissions
Now showing items 41-60 of 241
-
Dissecting the Genetic Basis of Variation in Drosophila Sleep Using a Multiparental QTL Mapping Resource
(MDPI, 2020-03-11)There is considerable variation in sleep duration, timing and quality in human populations, and sleep dysregulation has been implicated as a risk factor for a range of health problems. Human sleep traits are known to be ... -
Bacterial but Not Fungal Rhizosphere Community Composition Differ among Perennial Grass Ecotypes under Abiotic Environmental Stress
(American Society for Microbiology, 2022-04-20)Environmental change, especially frequent droughts, is predicted to detrimentally impact the North American perennial grasslands. Consistent dry spells will affect plant communities as well as their associated rhizobiomes, ... -
GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes
(2022-06-15)Rapid progress in structural modeling of proteins and their interactions is powered by advances in knowledge-based methodologies along with better understanding of physical principles of protein structure and function. The ... -
Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells
(Royal Society of Chemistry, 2018-04-30)The structure of novel binary nanosponges consisting of (cholesterol-(K/D)nDEVDGC)3-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)20 or aspartic acid (D)20 are tethered, has been ... -
Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase
(Taylor & Francis Open Access, 2022-05-05)Malaria is caused by infection with protozoan parasites of the Plasmodium genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast. The apicoplast genome ... -
DOCKGROUND membrane protein-protein set
(Public Library of Science, 2022-05-17)Membrane proteins are significantly underrepresented in Protein Data Bank despite their essential role in cellular mechanisms and the major progress in experimental protein structure determination. Thus, computational ... -
Global Probable Maximum Precipitation (PMP) Dataset
(2022-05-05) -
Hotspots for social and ecological impacts from freshwater stress and storage loss
(MDPI, 2022-01-21)Humans and ecosystems are deeply connected to, and through, the hydrological cycle. However, impacts of hydrological change on social and ecological systems are infrequently evaluated together at the global scale. Here, ... -
Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
(MDPI, 2022-03-17)We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence inhibitors. We identified from high-throughput screening assays a ... -
The American Congress Digital Archives Portal Project White Paper
(2022-04)This white paper documents the work of the American Congress Digital Archives Portal project to aggregate congressional archives into a single, online platform and make them more broadly available. Congressional archives ... -
Geomorphology variables predict fish assemblages for forested and endorheic rivers of two continents
(Wiley Open Access, 2021-11-26)Stream fishes are restricted to specific environments with appropriate habitats for feeding and reproduction. Interactions between streams and surrounding landscapes influence the availability and type of fish habitat, ... -
Novel Compound C150 Inhibits Pancreatic Cancer Cell Epithelial-to-Mesenchymal Transition and Tumor Growth in Mice
(Frontiers Media, 2021-12-15)Pancreatic cancer cell epithelial-to-mesenchymal transition (EMT) is an important contributor to cell invasion and tumor progression. Therefore, targeting EMT may be beneficial for pancreatic cancer treatment. The aim of ... -
Binding Analysis Using Accelerated Molecular Dynamics Simulations and Future Perspectives
(Dove Medical Press, 2021-02-20)Biomolecular recognition such as binding of small molecules, nucleic acids, peptides and proteins to their target receptors plays key roles in cellular function and has been targeted for therapeutic drug design. Molecular ... -
Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells
(Nature Research, 2020-04-20)Leukaemia stem cells (LSCs) underlie cancer therapy resistance but targeting these cells remains difficult. The Wnt–β-catenin and PI3K–Akt pathways cooperate to promote tumorigenesis and resistance to therapy. In a mouse ... -
Community structure of soil fungi in a novel perennial crop monoculture, annual agriculture, and native prairie reconstruction
(Public Library of Science, 2020-01-30)The use of perennial crop species in agricultural systems may increase ecosystem services and sustainability. Because soil microbial communities play a major role in many processes on which ecosystem services and sustainability ... -
The complete mitogenome of Leptestheria brevirostris Barnard, 1924, a rock pool clam shrimp (Branchiopoda: Spinicaudata) from Central District, Botswana
(Taylor & Francis Open Access, 2021-02-17)Spinicaudatan clam shrimp are a widespread and diverse group of branchiopod crustaceans, yet few mitochondrial genomes have been published for this taxonomic group. Here, we present the mitogenome of Leptestheria brevirostris ... -
Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations
(Cell Press, 2021-03-19)Here, we describe a generic protocol for monitoring protein-RNA interaction using a cleavable GFP fusion of a recombinant RNA-binding protein. We detail each expression and purification step, including high salt and heparin ... -
YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity
(MDPI, 2021-02-23)The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify ... -
Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB–DnaK bichaperone system
(Elsevier, 2020-11-13)The ClpB–DnaK bichaperone system reactivates aggregated cellular proteins and is essential for survival of bacteria, fungi, protozoa, and plants under stress. AAA+ ATPase ClpB is a promising target for the development of ... -
A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
(Elsevier, 2020-11-09)Conventionally, most amino acid substitutions at “important” protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of nonconserved positions for which ...
