An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC50 values.
This is the published version. Copyright Royal Society of Chemistry
Rogers, Steven A., Daniel C. Whitehead, Trey Mullikin, and Christian Melander. "Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-phenethyl) Carbamate Derivatives." Organic & Biomolecular Chemistry Org. Biomol. Chem. 8.17 (2010): 3857. DOI:10.1039/C0OB00063A
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