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Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance

dc.contributor.authorZhang, Ti
dc.contributor.authorCui, Huizhong
dc.contributor.authorFang, Chia-Yi
dc.contributor.authorSu, Long-Jyun
dc.contributor.authorRen, Shenqiang
dc.contributor.authorChang, Huan-Cheng
dc.contributor.authorYang, Xinmai
dc.contributor.authorForrest, M. Laird
dc.date.accessioned2015-10-29T19:58:23Z
dc.date.available2015-10-29T19:58:23Z
dc.date.issued2013-02-12
dc.identifier.citationZhang, Ti, Huizhong Cui, Chia-Yi Fang, Long-Jyun Su, Shenqiang Ren, Huan-Cheng Chang, Xinmai Yang, and M. Laird Forrest. "Photoacoustic Contrast Imaging of Biological Tissues with Nanodiamonds Fabricated for High Near-infrared Absorbance." J. Biomed. Opt Journal of Biomedical Optics 18.2 (2013): 026018. http://dx.doi.org/10.1117/1.JBO.18.2.026018en_US
dc.identifier.urihttp://hdl.handle.net/1808/18752
dc.description.abstractRadiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He+ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.en_US
dc.publisherSociety of Photo-optical Instrumentation Engineersen_US
dc.rights©2013 Zhang et al. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectPhotoacoustic imagingen_US
dc.subjectnanodiamondsen_US
dc.subjectAu nanorodsen_US
dc.subjectOptical contrast agenten_US
dc.titlePhotoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbanceen_US
dc.typeArticle
kusw.kuauthorYang, Xinmai
kusw.kudepartmentMechanical Engineeringen_US
dc.identifier.doi10.1117/1.JBO.18.2.026018
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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©2013 Zhang et al. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Except where otherwise noted, this item's license is described as: ©2013 Zhang et al. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.