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KU Med Center Dissertations and Theses: Recent submissions
Now showing items 421-440 of 464
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REGULATORY FUNCTIONS OF NOTCH SIGNALING IN EARLY EMBRYONIC VASCULAR DIFFERENTIATION AND VESSEL REMODELING
(University of Kansas, 2011-04-15)The signaling cascades that direct the morphological differentiation of the vascular system during early embryogenesis are not well defined. Several signaling pathways, including Notch and VEGF signaling, are critical for ... -
COST-EFFECTIVENESS OF INTRAVENOUS NICARDIPINE VERSUS SODIUM NITROPRUSSIDE FOR POSTOPERATIVE HYPERTENSION AFTER CARDIAC SURGERY.
(University of Kansas, 2010-11-23)Postoperative hypertension after cardiac surgery is common and associated with substantial morbidity. Both sodium nitroprusside (SNP) and nicardipine (NIC) are effective in its management. SNP is inexpensive, but associated ... -
Chemotherapy-Related Cognitive Impairment: The Breast Cancer Experience
(University of Kansas, 2010-10-11)The aims of this qualitative descriptive study were to describe the experience of chemotherapy-related cognitive impairment (CRCI) for women with breast cancer who received chemotherapy; and identify information about CRCI ... -
Mapping Auditory Nerve Firing Density using the Compound Action Potential and High-pass Noise Masking
(University of Kansas, 2010-09-10)A critical barrier to future implementation of regenerative treatments for sensorineural hearing loss is the lack of diagnostic tools that can specify the target(s) within the cochlea and auditory nerve for delivery of ... -
Vpu Mediated Enhancement of Human Immunodeficiency Virus Pathogenesis: The Role of Conserved and Unique Domains in Protein Function
(University of Kansas, 2010-12-14)The work in this dissertation examined the biological characteristics of different HIV-1 Vpu subtypes, with an emphasis on subtypes B and C, and the potential impact of these proteins on SHIV pathogenesis. Different Vpu ... -
THE EFFECT OF VOLUNATARY EXERCISE ON NEUROPATHIC PAIN
(University of Kansas, 2010-09-16)Neuropathic pain results from damage to peripheral sensory axons, which can occur due to physical trauma (via nerve trauma) or metabolic diseases (via diabetes). Neuropathic pain can be a debilitating disease that often ... -
Phosphatidylinositol-3 kinase/AKT and Fos like protein 1 regulation of trophoblast differentiation
(University of Kansas, 2010-09-02)Trophoblast cells are one of the earliest lineages to develop in the mammalian embryo. Trophoblast giant cells are the first trophoblast lineage to differentiate and have endocrine and invasive properties. This study focus ... -
Isolation and Characterization of Quiescent Intestinal Stem Cells
(University of Kansas, 2010-06-10)Critical to the identification of putative stem cell populations is the ability to evalu-ate their functional potential. Within this work I describe the development of a robust culture system which enables regeneration of ... -
DEVELOPMENT OF A SCREENING TOOL FOR IDENTIFYING YOUNG PEOPLE AT RISK FOR NOISE-INDUCED HEARING LOSS
(University of Kansas, 2010-07-23)This study surveyed common noise activities of young adults, quantified their annual equivalent noise exposures, and examined the efficacy of a self-assessment screening tool for identifying risk of noise-induced hearing ... -
Requirement for fibroblast growth factor receptor 1 in hematopoietic stem cells under stress but not during homeostasis
(University of Kansas, 2010-07-23)Fibroblast growth factor (FGF) signaling promotes hematopoietic stem cell (HSC) expansion in vitro; however, its in vivo function remains unknown. Conditional deletion of FGFR1, predominantly expressed in HSCs, did not ... -
Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function
(University of Kansas, 2010-07-30)Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the pathogenesis of sporadic breast cancers is poorly understood. We developed a functional assay, which assesses the ability ... -
Vitamin D Deficiency and Replacement: Relationships to Cardiovascular Health
(University of Kansas, 2010-04-11)Abstract Background: Cardiovascular disease is the most common cause of mortality and morbidity in the United States as well as many other nations. Recent evidence supports an association of vitamin D deficiency with ... -
Fruit and Vegetable Servings in Local Farm-Sourced and Standard Lunches Offered to Children in a Head Start Program
(University of Kansas, 2010-04-25)This project compared servings of fruits and vegetables consumed in farm-to-school lunches to that in conventional lunches served to students attending a Head Start preschool. The sample used was the student population of ... -
IMPROVING ACCESS TO CARDIOVASCULAR PREVENTIVE HEALTH CARE FOR THE UNINSURED POLISH POPULATION IN THE GREATER CHICAGO AREA-EXPERIENCE FROM THE POLISH AMERICAN ATHEROSCLEROSIS RISK FACTOR MODIFICATION (POLAARIS) PROJECT
(University of Kansas, 2010-04-13)Background: Healthcare system in United States is faced with a unique challenge of catering to a population that is racially, culturally and linguistically diverse.The Polish community in Chicago is one such. Objective: ... -
FACULTY AND STUDENT PERCEPTIONS OF PREPARATION FOR AND IMPLEMENTATION OF HIGH FIDELITY SIMULATION EXPERIENCES IN ASSOCIATE DEGREE NURSING PROGRAMS
(University of Kansas, 2009-01-01)High fidelity simulation technology is being used as an alternative way to expose students to complex patient care. Research has shown that simulation experiences can improve critical thinking skills and increase students‟ ... -
A MODEL OF THE RETRAUMATIZATION PROCESS: A META-SYNTHESIS OF CHILDHOOD SEXUAL ABUSE SURVIVORS' EXPERIENCES IN HEALTHCARE
(University of Kansas, 2010-01-28)Childhood sexual abuse survivors frequently report feeling retraumatized during routine healthcare encounters. The goal of this study was to develop a model to aid in understanding difficulties abuse survivors face when ... -
Effects of Hemorrhagic Shock and Fraction of Inspired Oxygen on Hydrogen Peroxide and Apoptosis in Rat Lung and Diaphragm
(University of Kansas, 2010-04-07)Abstract Hemorrhagic shock (HS) is the single most common cause of death in civilian and military personnel experiencing trauma (Alam & Rhee, 2007). Immediate resuscitation for HS can involve the administration of supplemental ... -
THE ELECTRONIC HEALTH RECORD FUNCTIONALITIES IN THE STATE OF KANSAS WITH REGARD TO NURSING PRACTICE
(University of Kansas, 2010-04-27)The purpose of this study was to identify the electronic health record functionalities of acute care hospitals in the state of Kansas with regard to nursing practice. From the perspective of the Chief Nursing Officer, what ... -
Perceived Readiness for Practice of Senior Baccalaureate Nursing Students
(University of Kansas, 2010-04-20)Nursing education is designed to assist students to become beginning practitioners and clinical experiences are essential to this process. As competition for clinical sites increases, educators need to establish best ... -
Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
(University of Kansas, 2010-04-27)Objective: Diabetes is heterogeneous group of disorders characterized by aberrant insulin signaling and hyperglycmia. Chronic hypergylcemia leads to the development of complications including diabetic peripheral neuropathy ...