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KU Med Center Dissertations and Theses: Recent submissions
Now showing items 221-240 of 464
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REAGGREGATION OF PANCREATIC ISLET CELLS: IMPLICATIONS FOR ISLET HEALTH, STORAGE AND NEW DRUG DISCOVERY
(University of Kansas, 2016-12-31)Islets are clusters of cells in the pancreas that monitor and regulate blood glucose levels. In culture, single islet cells reaggregate into clusters, but the reaggregation process is random, resulting in large variation ... -
HUMAN BOCAVIRUS 1 GENOME ORGANIZATION AND REPLICATION MECHANISM
(University of Kansas, 2016-12-31)Human bocavirus is a human pathogen that was identified in 2005. For the past decade, most of the studies about this virus were focused on clinical detection and its association-with diseases, while very little was known ... -
Contributions of Ouabain to the Autosomal Dominant Polycystic Kidney Disease Phenotype
(University of Kansas, 2016-12-31)Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder, caused by mutations in either of the PKD1 or PKD2 genes, which leads to the development and growth of multiple fluid-filled cysts in the kidney. ... -
IDENTIFICATION AND CHARACTERIZATION OF PATHWAYS REGULATED BY KDM4B IN OVARIAN CANCER
(University of Kansas, 2016-12-31)KDM4B is a hypoxia-inducible, histone lysine demethylase responsible for primarily demethylating H3K9 and H3K36. This enzyme has been implicated in the literature as a contributor to tumorigenesis in many solid tumor models. ... -
The Role of County-Level Socioeconomic Characteristics in Low-Income Women’s Use of Screening Mammography in Kansas
(University of Kansas, 2016-12-31)In the U.S., low-income, uninsured women have used mammography less frequently and have experienced higher breast cancer mortality rates than their wealthier and insured counterparts (Harper et al., 2009; National Center ... -
EXTRACELLULAR VESICLES IN OVARIAN ANTRAL FOLLICLES: CHARACTERIZATION AND FUNCTIONS
(University of Kansas, 2016-12-31)Formation of the follicular fluid antrum within the ovarian follicle provides a unique environment for the developing oocyte. Follicular fluid contains factors including nucleic acids, proteins, lipids, hormones, and ... -
BIOLOGICAL EFFECTS OF SPINAL MANIPULATION IN CHRONIC NON-SPECIFIC LOW BACK PAIN PATIENTS
(University of Kansas, 2016-12-31)Low back pain (LBP) affects up to 85% of the adult population imposing an economic burden of $86 billion annually or 1% of the US gross domestic product. Traditionally, acute spinal pain has been considered as self-resolving ... -
Vitamin B12 Deficiency in Individuals with Diabetic Neuropathy
(University of Kansas, 2016-12-31)Vitamin B12 is a water soluble vitamin known for its many deficiency symptoms. New studies on demographics and serum vitamin B12 levels conflict with past results. The purpose of this study was to evaluate the relationships ... -
Regulation of human trophoblast syncytialization by histone demethylase LSD1
(University of Kansas, 2016-12-31)A successful pregnancy is critically dependent upon proper placental development and function, beginning with differentiation of human trophoblast cells. At the final stage of trophoblast differentiation, the human placenta ... -
RNA-Seq Analysis Strategies and Ethical Considerations Involved in Precision Medicine
(University of Kansas, 2016-12-31)RNA-Seq has become the most recently and widely accepted method to evaluate gene expression. Though with RNA-Seq being a fairly green technology, analytical methods for its output data have not been fully investigated as ... -
Beta-catenin Associated Protein Complex Maintains Ground State Mouse Embryonic Stem Cell by Regulating Germline Development
(University of Kansas, 2016-12-31)Mouse embryonic stem (ES) cells cultured in defined medium with MEK and GSK3 inhibitors(2i) resemble the pre-implantation epiblast in the ground state, with full development capacity including the somatic lineages and the ... -
Observations on the early developments of the white rat (Rattus norvegicus albinus)
(University of Kansas, 1930) -
Advance Care Planning in the Marital Context: Dyadic Analyses of Advance Directive Completion by Older Married Adults
(University of Kansas, 2016-12-31)Advance directive completion is associated with higher quality care at the end of life and increased odds of receiving hospice care and of dying at home. Researchers seeking to understand why some older adults complete ... -
The effects of prolonged administrations of methyl guanidine sulphate on the blood pressures of non-anesthetized dogs
(University of Kansas, 1930) -
The Modified Rapid Emergency Medicine Score: A Novel Trauma Triaging Tool for Predicting In-hospital Mortality
(University of Kansas, 2016-05-31)Objectives: Trauma systems currently rely on imperfect and subjective tools to prioritize responses and resources, thus there is a critical need to develop a more accurate trauma severity score. Our objective was to modify ... -
Multi-Parameter Flow Cytometric Analysis of Ikaros Family Expression in Human T Cell Development and T-ALL
(University of Kansas, 2016-05-31)The Ikaros family transcription factors are critical regulators of T cell development and leukemogenesis. Loss of function of all five family members leads to an early block in murine lymphocyte development, whereas reduced ... -
ROLES OF TMIGD3 AND A3AR IN SUPPRESSION OF OSTEOSARCOMA MALIGNANCY
(University of Kansas, 2016-05-31)Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Despite advances in the treatment for OS, the survival rate of high-grade OS has reached a plateau and remains at 50-80% ... -
PRESSURE ULCERS AND PREVENTION AMONG PEDIATRIC PATIENTS AND FACTORS ASSOCIATED WITH THEIR OOCCURENCE IN ACUTE CARE HOSPITALS
(University of Kansas, 2015-08-31)Abstract Introduction: Pressure ulcers are a health-care concern for all patient populations; however, younger patients, including infants, have different etiologies associated with pressure ulcer development. The influence ... -
Residential Satisfaction, Psychological Well-Being, and Personality Traits: Effects on Relocation among Older Adults
(University of Kansas, 2014-08-31)The focus of this study is the moves made voluntarily in later life. Older adults who engage in voluntary late life relocation are more likely to be white, have better health, have higher socioeconomic status, and have ... -
CHARACTERIZATION OF THE ONTOGENY AND INTER-INDIVIDUAL VARIATION OF GENES IN CHOLESTEROL AND STATIN PATHWAYS
(University of Kansas, 2015-05-31)Introduction: Previous studies have shown that gene expression can change throughout development,1 and therefore genotype-phenotype associations found in adults might not be observed in children of all ages. The purpose ...