KU Med Center Dissertations and Theses: Recent submissions
Now showing items 21-40 of 464
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The Impact of Type 2 Diabetes and Associated Diabetic Peripheral Neuropathy on Grip Force Control and Hand Function
(University of Kansas, 2019-12-31)There is cumulative evidence that fine motor skills and hand function are deficient in individuals with type 2 diabetes (T2D) and associated diabetic peripheral neuropathy (DPN). This might impact their ability to perform ... -
Prediction of random effects in mixed effects models under violations of the normality assumption for the random-effects and a graphical approach to detect violations
(University of Kansas, 2019-12-31)In longitudinal data analysis, the introduction of random effects provides statisticians with a convenient tool for modeling repeated measurements. Mixed effects linear models extend linear and generalized linear models ... -
Lola-I is a promoter pioneer factor that regulates RNA polymerase II pausing during Drosophila embryogenesis
(University of Kansas, 2019-12-31)Transcriptionally engaged Pol II has been observed at many inactive genes, in a paused state. Since Pol II can be found even in the inactive state, is Pol II recruited to these genes by default? If the recruitment of Pol ... -
Statistical Evaluation of Drug Safety in Clinical Trials
(University of Kansas, 2019-12-31)The evaluation of drug safety is critically important in clinical trials. The first part of this dissertation explores new statistical methods for drug safety signal detection in two-arm clinical trials. Current statistical ... -
Learning about Techniques to Create Healthy Infants through Nutrition and Proper Growth: The LATCHING Pilot Project
(University of Kansas, 2019-12-31)Abstract Background: Despite numerous benefits for both mom and baby, early cessation of breastfeeding and introduction of solids is common. Interventions to improve breastfeeding rates and prevent the early introduction ... -
Gait Analysis Post Anterior Cruciate Ligament Reconstruction Using Inertial Sensors: A Longitudinal Study
(University of Kansas, 2019-12-31)Altered gait patterns may persist for months or even years in patients after anterior cruciate ligament reconstruction (ACLR). The persistence of these deficits during walking or running activities is of serious concern, ... -
The Impact of Diabetes on Osteoarthritis Prevalence and Pain
(University of Kansas, 2019-12-31)A growing body of evidence shows that there is an association between osteoarthritis (OA) and Type 2 diabetes mellitus (DM). However, the impact of DM on OA prevalence, specific OA locations, and pain remain poorly understood. ... -
THE RELATIONSHIP OF NURSE MANAGER COMPETENCIES, NURSE PRACTICE ENVIRONMENT, AND FRONTLINE NURSES’ INTENT TO STAY: A MEDIATION ANALYSIS
(University of Kansas, 2019-05-31)The high rate of nurse turnover can have a profound impact on the already diminishing nursing workforce. With the predicted nursing shortage, it is important to mitigate the factors that lead to turnover. Practice ... -
Best Teaching Practices for Providing Culturally Sensitive and Inclusive Nursing Education: Nurse Educators’ Perspectives
(University of Kansas, 2019-05-31)This paper explored problem-based learning and cultural diversity, critical thinking and clinical judgment and cultural diversity, and nurse educators’ perceptions of implementing culturally diverse and inclusive nursing ... -
Topics in Goodness-of-fit Test for Logistic Regression Models with Continuous Covariates
(University of Kansas, 2019-05-31)There is no phenomenal method practitioners can use as a appropriate tool for model validation when sparse data are presented in multiple logistic regression models. The characteristics of sparsity, i.e. very few number ... -
Exploring How Nurses’ Perceptions of Nurse Managers’ Communication Influence their Buy-In to Initiatives to Support Patients’ Experiences with Care
(University of Kansas, 2019-05-31)Abstract Introduction. The continually evolving healthcare environment requires healthcare leaders to better understand how to engage clinicians to support desired organizational change. Nursing remains the dominant ... -
Assessing the Relationship Between Prenatal DHA Status on Offspring Body Composition
(University of Kansas, 2019-05-31)ABSTRACT Background: As childhood obesity rates continue to rise, it is crucial to discover more effective prevention strategies. Most obesity prevention treatment strategies are implemented in school-age children. However, ... -
Are We Failing the Homeless and Uninsured Trauma Patient? An Exploration in the Nurse Practitioner Role in Trauma, and Identification of Disparity in Treatment and Barriers to Follow-up for the Acutely Injured
(University of Kansas, 2019-05-31)The purpose of this dissertation was to examine disparities in healthcare related to insurance status and homelessness through three scholarly projects. Within the projects, the nurse practitioner’s role for trauma care ... -
Aerobic Walking Exercise for Non-ambulatory Stroke Survivors
(University of Kansas, 2019-05-31)Stroke is a major cause of permanent disability worldwide. In the United States, stroke is the leading cause of disability and the 5th leading cause of death. The cost of care associated with stroke is expected to be $184 ... -
The influence of diet and exercise on early life stress-induced co-morbid disorders in mice
(University of Kansas, 2019-05-31)Individuals with functional pain disorders often present with symptoms of or are diagnosed with more than one disorder. Furthermore, these patients with co-morbid pain disorders are also more likely to present with mood ... -
Prediction Models for Cancer Risk and Prognosis using Clinical and DNA Methylation Biomarkers: Considerations in Study Design and Model Development
(University of Kansas, 2019-05-31)The ability to accurately predict the prognosis for any given disease is of immense value for clinicians and patients. It can dictate and optimize an individual treatment plan for a patient and ultimately improve their ... -
Examining Enrollment Barriers to Adult Cancer Clinical Trials
(University of Kansas, 2019-05-31)Advancing knowledge in cancer treatment can only be achieved with the conduct of clinical trials. Barriers to adult cancer clinical trial participation have been extensively examined, yet nearly 20% of trials fail due to ... -
Sedentary Behavior in People with Type 2 Diabetes
(University of Kansas, 2018-12-31)Sedentary behavior is a major health issue in people with type 2 diabetes (T2D). Many people with T2D are sedentary despite strong recommendations of regular physical activity. Studies that investigate the complex nature ... -
Designing an Effective Skill Learning Environment
(University of Kansas, 2018-12-31)This paper explored the dynamic process of psychomotor skill development. The design of effective skill development experiences requires the integration of a complex mosaic of interacting factors having the ultimate goal ... -
Role of primary cilia-mediated signaling in human and mouse models of Autosomal Dominant Polycystic Kidney Disease
(University of Kansas, 2018-12-31)Primary cilia are non-motile microtubule-based organelles that extend from the apical plasma membrane of most vertebrate cells and mediate signaling pathways. Mutations in ciliary genes often result in renal cyst formation, ...