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dc.contributor.authorChannell, Marie Moore
dc.contributor.authorPhillips, B. Allyson
dc.contributor.authorLoveall, Susan J.
dc.contributor.authorConners, Frances A.
dc.contributor.authorBussanich, Paige M.
dc.contributor.authorKlinger, Laura Grofer
dc.date.accessioned2015-06-09T19:12:07Z
dc.date.available2015-06-09T19:12:07Z
dc.date.issued2014-04-07
dc.identifier.citationChannell, Marie Moore, B. Allyson Phillips, Susan Loveall, Frances Conners, Paige M. Bussanich, and Laura Grofer Klinger. "Patterns of Autism Spectrum Symptomatology in Individuals with Down Syndrome without Comorbid Autism Spectrum Disorder." Journal of Neurodevelopmental Disorders 7.5 (2015): n. pag. http://dx.doi.org/10.1186/1866-1955-7-5.en_US
dc.identifier.urihttp://hdl.handle.net/1808/18053
dc.description.abstractBackground

Prevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a syndrome that carries its own set of social communicative and behavioral difficulties that are not well documented. The aim of this study was to identify the typical range of social communicative impairments observed in children, adolescents, and young adults with DS who do not have comorbid ASD. Methods

We examined patterns of scores from the five subscales of the Social Responsiveness Scale (SRS) in 46 individuals with DS (ages 10–21 years) without comorbid ASD relative to the published normative sample. We also explored the correlations between SRS symptomatology and age, nonverbal cognition, and receptive language. Results

SRS scores were elevated (i.e., more ASD symptoms endorsed), with mean scores falling into the clinically significant range. Analysis by subscale revealed a specific pattern, with Autistic Mannerisms and Social Cognition scores significantly more elevated than Social Communication scores, which were significantly more elevated than Social Awareness and Social Motivation scores. Correlations between SRS scores and the other measures varied by subscale. Conclusions

General elevated ASD symptomatology on the SRS indicates the need for developing population-based norms specific to DS. The pattern of scores across subscales should inform clinicians of the typical range of behaviors observed in DS so that individuals with atypical patterns of behavior can be more easily identified and considered for a full ASD evaluation.
en_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofhttp://www.jneurodevdisorders.com/content/7/1/5en_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDown syndromeen_US
dc.subjectAutism spectrum disorderen_US
dc.subjectComorbidityen_US
dc.subjectSocial communicationen_US
dc.subjectIntellectual disablityen_US
dc.titlePatterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorderen_US
dc.typeArticle
kusw.kuauthorLoveall, Susan
kusw.kudepartmentLife Span Instituteen_US
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.