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    Glycation and diabetes: The RAGE connection

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    YanShirley_CS_83(12)1515.pdf (49.62Kb)
    Issue Date
    2002-12-25
    Author
    Hudson, Barry I.
    Hofmann, Marion A.
    Bucciarelli, Loredana
    Wendt, Thoralf
    Moser, Bernhard
    Lu, Yan
    Qu, Wu
    Stern, David M.
    D'Agati, Vivette
    Yan, Shirley ShiDu
    Yan, Shi Fang
    Grant, Peter J.
    Schmidt, Ann Marie
    Publisher
    Current Science Assoication
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Published Version
    http://www.currentscience.ac.in/php/toc.php?vol=083&issue=12
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    Abstract
    The hyperglycaemic state seen in diabetes mellitus is associated with the development of diabetes-specific microvascular complications and accelerated macrovascular disease. Evidence implicates the formation and subsequent effects of advanced glycation endproducts (AGEs) as a contributing cause. AGEs exert their effects through interaction with the Receptor for AGE (RAGE) which upregulates expression of the receptor and induces a cascade of cytotoxic pathways. Accumulation of AGE/RAGE can be seen at sites of vascular disease in both animal models of diabetes and human diabetic subjects. Blockade of RAGE in animal models of diabetes suppresses development of dysfunction in the vasculature and atherosclerosis development. Genetic studies of RAGE reveal that a number of allelic variants of RAGE occur in key protein and regulatory domains. A Gly to Ser change at position 82 and two 5¢¢ flanking polymorphisms at position –374 and –429 lead to altered function and expression of RAGE which may impact on diabetic vascular disease development. Therapy aimed to block RAGE upregulation may prove to be useful in treating individuals with diabetic vascular disease.
    URI
    http://hdl.handle.net/1808/17792
    Collections
    • Pharmaceutical Chemistry Scholarly Works [336]
    Citation
    Hudson et al. "Glycation and diabetes: The RAGE connection." Current Science, Vol. 83, No12, 25 December 2002. http://www.currentscience.ac.in/php/toc.php?vol=083&issue=12

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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