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    17β-Estradiol and Progesterone Regulate Expression of β-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain

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    ZhaoL_Endo_153(11)5467.pdf (1.695Mb)
    Issue Date
    2012
    Author
    Jayaraman, Anusha
    Carroll, Jenna C.
    Morgan, Todd E.
    Lin, Sharon W.
    Zhao, Liqin
    Arimoto, Jason M.
    Murphy, M. Paul
    Beckett, Tina L.
    Finch, Caleb E.
    Brinton, Roberta Diaz
    Pike, Christian J.
    Publisher
    Endocrine Society
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    The accumulation of β-amyloid protein (Aβ) is a key risk factor in the development of Alzheimer's disease. The ovarian sex steroid hormones 17β-estradiol (E2) and progesterone (P4) have been shown to regulate Aβ accumulation, although the underlying mechanism(s) remain to be fully elucidated. In this study, we investigate the effects of E2 and P4 treatment on the expression levels of Aβ clearance factors including insulin-degrading enzyme, neprilysin, endothelin-converting enzyme 1 and 2, angiotensin-converting enzyme, and transthyretin, both in primary neuron cultures and female rat brains. Our results show that E2 and P4 affect the expression levels of several Aβ clearance factors in dose- and time-dependent manners. Most notably, expression of insulin-degrading enzyme is significantly increased by both hormones in cultured neurons and in vivo and is inversely associated with the soluble Aβ levels in vivo. These findings further define sex steroid hormone actions involved in regulation of Aβ, a relationship potentially important to therapeutic approaches aimed at reducing risk of Alzheimer's disease.
    URI
    http://hdl.handle.net/1808/17750
    DOI
    https://doi.org/10.1210/en.2012-1464
    Collections
    • Pharmaceutical Chemistry Scholarly Works [336]
    Citation
    Jayaraman et. al. "17β-Estradiol and Progesterone Regulate Expression of β-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain." Endocrinology, November 2012, 153(11):5467–5479. http://dx.doi.org/10.1210/en.2012-1464

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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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