ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
9-(trans-2',trans-3'-Dihydroxycyclopent-4'-Enyl)-Adenine and -3-Deazaadenine: Analogs of Neplanocin A Which Retain Potent Antiviral Activity but Exhibit Reduced Cytotoxicity
dc.contributor.author | Hasobe, Masahide | |
dc.contributor.author | McKee, James G. | |
dc.contributor.author | Borcherding, David R. | |
dc.contributor.author | Borchardt, Ronald T. | |
dc.date.accessioned | 2015-05-08T15:53:46Z | |
dc.date.available | 2015-05-08T15:53:46Z | |
dc.date.issued | 1987-11 | |
dc.identifier.citation | Hasobe et. al. "9-(trans-2',trans-3'-Dihydroxycyclopent-4'-Enyl)-Adenine and -3-Deazaadenine: Analogs of Neplanocin A Which Retain Potent Antiviral Activity but Exhibit Reduced Cytotoxicity." Antimicrob. Agents Chemother. November 1987 vol. 31 no. 11 1849-1851.http://dx.doi.org/10.1128/AAC.31.11.1849 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17659 | |
dc.description.abstract | Two synthetic analogs of neplanocin A, which were shown in a separate study to be inhibitors of S-adenosylhomocysteine hydrolase and devoid of substrate activity with adenosine kinase, were found in this study to inhibit vaccinia virus replication in murine L929 cells but to have reduced cytotoxicity compared with that of the parent compound. These results confirm that S-adenosylhomocysteine hydrolase is the molecular target which mediates the antiviral effects of neplanocin A and that transformation by cellular adenosine kinase mediates its cytotoxic properties. | en_US |
dc.description.sponsorship | This work was supported by Public Health Service research grant GM-29332 from the National Institutes of Health. | en_US |
dc.publisher | The American Society for Microbiology | en_US |
dc.title | 9-(trans-2',trans-3'-Dihydroxycyclopent-4'-Enyl)-Adenine and -3-Deazaadenine: Analogs of Neplanocin A Which Retain Potent Antiviral Activity but Exhibit Reduced Cytotoxicity | en_US |
dc.type | Article | |
kusw.kuauthor | Hasobe, Masahide | |
kusw.kuauthor | McKee, James G. | |
kusw.kuauthor | Borcherding, David R. | |
kusw.kuauthor | Borchardt, Ronald T. | |
kusw.kudepartment | Department of Pharmaceutical Chemisty | en_US |
dc.identifier.doi | 10.1128/AAC.31.11.1849 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |