Show simple item record

dc.contributor.authorHasobe, Masahide
dc.contributor.authorMcKee, James G.
dc.contributor.authorBorcherding, David R.
dc.contributor.authorBorchardt, Ronald T.
dc.date.accessioned2015-05-08T15:53:46Z
dc.date.available2015-05-08T15:53:46Z
dc.date.issued1987-11
dc.identifier.citationHasobe et. al. "9-(trans-2',trans-3'-Dihydroxycyclopent-4'-Enyl)-Adenine and -3-Deazaadenine: Analogs of Neplanocin A Which Retain Potent Antiviral Activity but Exhibit Reduced Cytotoxicity." Antimicrob. Agents Chemother. November 1987 vol. 31 no. 11 1849-1851.

http://dx.doi.org/10.1128/AAC.31.11.1849
en_US
dc.identifier.urihttp://hdl.handle.net/1808/17659
dc.description.abstractTwo synthetic analogs of neplanocin A, which were shown in a separate study to be inhibitors of S-adenosylhomocysteine hydrolase and devoid of substrate activity with adenosine kinase, were found in this study to inhibit vaccinia virus replication in murine L929 cells but to have reduced cytotoxicity compared with that of the parent compound. These results confirm that S-adenosylhomocysteine hydrolase is the molecular target which mediates the antiviral effects of neplanocin A and that transformation by cellular adenosine kinase mediates its cytotoxic properties.en_US
dc.description.sponsorshipThis work was supported by Public Health Service research grant GM-29332 from the National Institutes of Health.en_US
dc.publisherThe American Society for Microbiologyen_US
dc.title9-(trans-2',trans-3'-Dihydroxycyclopent-4'-Enyl)-Adenine and -3-Deazaadenine: Analogs of Neplanocin A Which Retain Potent Antiviral Activity but Exhibit Reduced Cytotoxicityen_US
dc.typeArticle
kusw.kuauthorHasobe, Masahide
kusw.kuauthorMcKee, James G.
kusw.kuauthorBorcherding, David R.
kusw.kuauthorBorchardt, Ronald T.
kusw.kudepartmentDepartment of Pharmaceutical Chemistyen_US
dc.identifier.doi10.1128/AAC.31.11.1849
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record