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dc.contributor.authorde Clercq, Erik
dc.contributor.authorCools, Marina
dc.contributor.authorBalzarini, Jan
dc.contributor.authorMarquez, Victor E.
dc.contributor.authorBorcherding, David R.
dc.contributor.authorBorchardt, Ronald T.
dc.contributor.authorDrach, John C.
dc.contributor.authorKitaoka, Setsuko
dc.contributor.authorKonno, Tasuke
dc.date.accessioned2015-05-08T15:31:22Z
dc.date.available2015-05-08T15:31:22Z
dc.date.issued1989-05-09
dc.identifier.citationClercq et al. "Broad-Spectrum Antiviral Activities of Neplanocin A, 3-Deazaneplanocin A, and Their 5'-Nor Derivatives." Antimicrob. Agents Chemother. August 1989 vol. 33 no. 8 1291-1297.

http://dx.doi.org/10.1128/AAC.33.8.1291
en_US
dc.identifier.urihttp://hdl.handle.net/1808/17657
dc.description.abstractThe neplanocin A analogs, 3-deazaneplanocin A, 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)adenine (DHCA), and 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-3-deazaadenine (DHCDA), all potent inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, were studied for their broad-spectrum antiviral potential. 3-Deazaneplanocin A, DHCA, and DHCDA proved specifically effective against vesicular stomatitis virus, vaccinia virus, parainfluenza virus, reovirus, and rotavirus. Their selectivity was greater than that of neplanocin A, particularly against vesicular stomatitis virus and rotavirus. As could be expected from adenosine analogs that are directly targeted at AdoHcy hydrolase, 3-deazaneplanocin A, DHCA, and DHCDA were fully active in adenosine kinase-deficient cells, implying that their activity did not depend on phosphorylation by adenosine kinase. None of the AdoHcy hydrolase inhibitors showed selective activity against human immunodeficiency virus (type 1). 3-Deazaneplanocin A at a dose of 0.5 mg/kg per day conferred marked protection against a lethal infection of newborn mice with vesicular stomatitis virus.en_US
dc.description.sponsorshipThis work was supported by the Belgian Fonds voor Geneeskundig Wetenschappelijk Onderzoek (project no. 3.0040.83) and the Belgian Geconcerteerde Onderzoeksacties (project no. 85/90-79). We thank Anita Van Lierde, Frieda De Meyer, Ria Van Berwaer, Ann Absillis, Etsuko Nitanai, and Willy Zeegers for excellent technical assistance and Christiane Callebaut for fine editorial help.en_US
dc.publisherThe American Society for Microbiologyen_US
dc.titleBroad-Spectrum Antiviral Activities of Neplanocin A, 3-Deazaneplanocin A, and Their 5'-Nor Derivativesen_US
dc.typeArticle
kusw.kuauthorBorcherding, David R.
kusw.kuauthorBorchardt, Ronald T.
kusw.kudepartmentDepartment of Pharmaceutical Chemistyen_US
dc.identifier.doi10.1128/AAC.33.8.1291
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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