An apparent ethical dilemma arises when physicians consider enrolling their patients in randomized clinical trials. Suppose that a randomized clinical trial comparing two treatments is in progress, and a physician has an opinion about which treatment is better. The physician has a duty to promote the patient's best medical interests and therefore seems to be obliged to advise the patient to receive the treatment that the physician prefers. This duty creates a barrier to the enrollment of patients in randomized clinical trials.1-10 Two strategies are often used to resolve the dilemma in favor of enrolling patients in clinical trials.
Marquis, Don. "How to Resolve an Ethical Dilemma Concerning Randomized Clinical Trials." The New England Journal of Medicine Volume 341 Number 9 691-3. http://www.dx.doi.org/10.1056/NEJM199908263410912