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dc.contributor.authorHanson, Paul R.
dc.contributor.authorJayasinghe, Susanthi
dc.contributor.authorMaitra, Soma
dc.contributor.authorNdi, Cornelius N.
dc.contributor.authorChegondi, Rambabu
dc.date.accessioned2014-11-13T21:35:08Z
dc.date.available2014-11-13T21:35:08Z
dc.date.issued2014-10-07
dc.identifier.citationPaul R Hanson, Susanthi Jayasinghe, Soma Maitra, Cornelius N Ndi, Rambabu Chegondi. "A modular phosphate tether-mediated divergent strategy to complex polyols." Beilstein J Org Chem. 2014; 10: 2332–2337. Published online 2014 October 7. http://dx.doi.org/10.3762/bjoc.10.242
dc.identifier.urihttp://hdl.handle.net/1808/15750
dc.descriptionThis investigation was generously supported by funds provided by the National Institute of General Medical Sciences (NIH R01 GM077309). The authors thank Dr. Justin Douglas and Sarah Neuenswander (KU) for assistance with NMR measurements and Dr. Todd Williams (KU) for HRMS analysis. The authors also thank the University of Kansas and the State of Kansas for support of our program. The authors also thank Materia, Inc. for supplying the metathesis catalyst.
dc.description.abstractAn efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C 2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
dc.description.sponsorship© 2014, Hanson et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
dc.publisherBeilstein-Institut
dc.subjectPhosphate Tether
dc.subjectOne-pot
dc.subjectSequential Processes
dc.subjectOrganophosphorus
dc.subjectPolyol
dc.subjectStereodivergent
dc.titleA modular phosphate tether-mediated divergent strategy to complex polyols
dc.typeArticle
kusw.kuauthorHanson, Paul R.
kusw.kuauthorJayasonghe, Susanthi
kusw.kuauthorMaitra, Soma
kusw.kuauthorNdi, Cornelius N.
kusw.kuauthorChegondi, Rambabu
kusw.kudepartmentDepartment of Chemistry
kusw.oastatusfullparticipation
dc.identifier.doi10.3762/bjoc.10.242
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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