Show simple item record

dc.contributor.authorLiliensiek, Birgit
dc.contributor.authorWeigand, Markus A.
dc.contributor.authorBierhaus, Angelika
dc.contributor.authorNicklas, Werner
dc.contributor.authorKasper, Michael
dc.contributor.authorHofer, Stefan
dc.contributor.authorPlachky, Jens
dc.contributor.authorGröne, Herman-Josef
dc.contributor.authorKurschus, Florian C.
dc.contributor.authorSchmidt, Ann Marie
dc.contributor.authorYan, Shirley ShiDu
dc.contributor.authorMartin, Eike
dc.contributor.authorSchleicher, Erwin
dc.contributor.authorStern, David M.
dc.contributor.authorHämmerling, Günter J.
dc.contributor.authorNawroth, Peter P.
dc.contributor.authorArnold, Bernd
dc.date.accessioned2014-07-22T16:31:18Z
dc.date.available2014-07-22T16:31:18Z
dc.date.issued2004-06-01
dc.identifier.citationLiliensiek, Birgit et al. (2004). Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. Journal of Clinical Investigation 113(11):1641-50. http://www.dx.doi.org/10.1172/JCI18704
dc.identifier.issn0021-9738
dc.identifier.urihttp://hdl.handle.net/1808/14816
dc.descriptionThis is the publisher's version, also available electronically from http://www.jci.org/articles/view/18704
dc.description.abstractWhile the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.
dc.publisherAmerican Society for Clinical Investigation
dc.titleReceptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
dc.typeArticle
kusw.kuauthorYan, Shirley ShiDu
kusw.kudepartmentPharmacology & Toxicology
kusw.oastatusfullparticipation
dc.identifier.doi10.1172/JCI18704
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record