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    Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

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    Yan_et_al_2004.pdf (668.5Kb)
    Issue Date
    2004-06-01
    Author
    Liliensiek, Birgit
    Weigand, Markus A.
    Bierhaus, Angelika
    Nicklas, Werner
    Kasper, Michael
    Hofer, Stefan
    Plachky, Jens
    Gröne, Herman-Josef
    Kurschus, Florian C.
    Schmidt, Ann Marie
    Yan, Shirley ShiDu
    Martin, Eike
    Schleicher, Erwin
    Stern, David M.
    Hämmerling, Günter J.
    Nawroth, Peter P.
    Arnold, Bernd
    Publisher
    American Society for Clinical Investigation
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.
    Description
    This is the publisher's version, also available electronically from http://www.jci.org/articles/view/18704
    URI
    http://hdl.handle.net/1808/14816
    DOI
    https://doi.org/10.1172/JCI18704
    ISSN
    0021-9738
    Collections
    • Pharmacy Scholarly Works [293]
    Citation
    Liliensiek, Birgit et al. (2004). Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. Journal of Clinical Investigation 113(11):1641-50. http://www.dx.doi.org/10.1172/JCI18704

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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