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Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
dc.contributor.author | Cao, Pengxiu | |
dc.contributor.author | Yuan, Yiyuan | |
dc.contributor.author | Pehek, Elizabeth A. | |
dc.contributor.author | Moise, Alexander R. | |
dc.contributor.author | Huang, Ying | |
dc.contributor.author | Palczewski, Krzysztof | |
dc.contributor.author | Feng, Zhaoyang | |
dc.date.accessioned | 2014-07-21T21:10:08Z | |
dc.date.available | 2014-07-21T21:10:08Z | |
dc.date.issued | 2010-02-19 | |
dc.identifier.citation | Cao, Penxiu et al. (2010). Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans. PLOS One 5(2):e9312. http://www.dx.doi.org/10.1371/journal.pone.0009312 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/1808/14801 | |
dc.description | This is the publisher's version, also available electronically from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009312 | |
dc.description.abstract | Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human α-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of α-synuclein on dopamine homeostasis and its contribution to dopaminergic neuron degeneration in C. elegans have not been reported. Here, we examined the effects of α-synuclein overexpression on worm dopamine homeostasis. We found that α-synuclein expression results in upregulation of dopamine synthesis and content, and redistribution of dopaminergic synaptic vesicles, which significantly contribute to dopaminergic neuron degeneration. These results provide in vivo evidence supporting a critical role for dopamine homeostasis in supporting dopaminergic neuron integrity. | |
dc.publisher | Public Library of Science | |
dc.title | Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans | |
dc.type | Article | |
kusw.kuauthor | Moise, Alexander R. | |
kusw.kudepartment | Pharmacology & Toxicology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1371/journal.pone.0009312 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2307-6035 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Pharmacy Scholarly Works [299]