ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Show simple item record

dc.contributor.authorCao, Pengxiu
dc.contributor.authorYuan, Yiyuan
dc.contributor.authorPehek, Elizabeth A.
dc.contributor.authorMoise, Alexander R.
dc.contributor.authorHuang, Ying
dc.contributor.authorPalczewski, Krzysztof
dc.contributor.authorFeng, Zhaoyang
dc.date.accessioned2014-07-21T21:10:08Z
dc.date.available2014-07-21T21:10:08Z
dc.date.issued2010-02-19
dc.identifier.citationCao, Penxiu et al. (2010). Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans. PLOS One 5(2):e9312. http://www.dx.doi.org/10.1371/journal.pone.0009312
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1808/14801
dc.descriptionThis is the publisher's version, also available electronically from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009312
dc.description.abstractDisruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human α-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of α-synuclein on dopamine homeostasis and its contribution to dopaminergic neuron degeneration in C. elegans have not been reported. Here, we examined the effects of α-synuclein overexpression on worm dopamine homeostasis. We found that α-synuclein expression results in upregulation of dopamine synthesis and content, and redistribution of dopaminergic synaptic vesicles, which significantly contribute to dopaminergic neuron degeneration. These results provide in vivo evidence supporting a critical role for dopamine homeostasis in supporting dopaminergic neuron integrity.
dc.publisherPublic Library of Science
dc.titleAlpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
dc.typeArticle
kusw.kuauthorMoise, Alexander R.
kusw.kudepartmentPharmacology & Toxicology
kusw.oastatusfullparticipation
dc.identifier.doi10.1371/journal.pone.0009312
dc.identifier.orcidhttps://orcid.org/0000-0003-2307-6035
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record