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    Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans

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    Moise_et_al_2010.pdf (1.358Mb)
    Issue Date
    2010-02-19
    Author
    Cao, Pengxiu
    Yuan, Yiyuan
    Pehek, Elizabeth A.
    Moise, Alexander R.
    Huang, Ying
    Palczewski, Krzysztof
    Feng, Zhaoyang
    Publisher
    Public Library of Science
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human α-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of α-synuclein on dopamine homeostasis and its contribution to dopaminergic neuron degeneration in C. elegans have not been reported. Here, we examined the effects of α-synuclein overexpression on worm dopamine homeostasis. We found that α-synuclein expression results in upregulation of dopamine synthesis and content, and redistribution of dopaminergic synaptic vesicles, which significantly contribute to dopaminergic neuron degeneration. These results provide in vivo evidence supporting a critical role for dopamine homeostasis in supporting dopaminergic neuron integrity.
    Description
    This is the publisher's version, also available electronically from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009312
    URI
    http://hdl.handle.net/1808/14801
    DOI
    https://doi.org/10.1371/journal.pone.0009312
    ISSN
    1932-6203
    Collections
    • Pharmacy Scholarly Works [286]
    Citation
    Cao, Penxiu et al. (2010). Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans. PLOS One 5(2):e9312. http://www.dx.doi.org/10.1371/journal.pone.0009312

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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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