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Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release
dc.contributor.author | Moise, Alexander R. | |
dc.contributor.author | Grant, Jason R. | |
dc.contributor.author | Vitalis, Timothy Z. | |
dc.contributor.author | Jefferies, Wilfred A. | |
dc.date.accessioned | 2014-07-21T20:33:43Z | |
dc.date.available | 2014-07-21T20:33:43Z | |
dc.date.issued | 2002-02 | |
dc.identifier.citation | Moise, Alexander et al. (2002). Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release. Journal of Virology 76(4):1578-1587. http://www.dx.doi.org/10.1128/JVI.76.4.1578-1587.2002 | |
dc.identifier.issn | 0022-538X | |
dc.identifier.uri | http://hdl.handle.net/1808/14798 | |
dc.description | This is the publisher's version, also available electronically from http://jvi.asm.org/content/76/4/1578 | |
dc.description.abstract | E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca2+ homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca2+ flux-induced and death receptor-mediated apoptosis. | |
dc.publisher | American Society for Microbiology | |
dc.title | Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release | |
dc.type | Article | |
kusw.kuauthor | Moise, Alexander R. | |
kusw.kudepartment | Pharmacology & Toxicology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1128/JVI.76.4.1578-1587.2002 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2307-6035 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Pharmacy Scholarly Works [299]