Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release

Moise, Alexander R.; Grant, Jason R.; Vitalis, Timothy Z.; Jefferies, Wilfred A.

dc.contributor.author	Moise, Alexander R.
dc.contributor.author	Grant, Jason R.
dc.contributor.author	Vitalis, Timothy Z.
dc.contributor.author	Jefferies, Wilfred A.
dc.date.accessioned	2014-07-21T20:33:43Z
dc.date.available	2014-07-21T20:33:43Z
dc.date.issued	2002-02
dc.identifier.citation	Moise, Alexander et al. (2002). Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release. Journal of Virology 76(4):1578-1587. http://www.dx.doi.org/10.1128/JVI.76.4.1578-1587.2002
dc.identifier.issn	0022-538X
dc.identifier.uri	http://hdl.handle.net/1808/14798
dc.description	This is the publisher's version, also available electronically from http://jvi.asm.org/content/76/4/1578
dc.description.abstract	E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca2+ homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca2+ flux-induced and death receptor-mediated apoptosis.
dc.publisher	American Society for Microbiology
dc.title	Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release
dc.type	Article
kusw.kuauthor	Moise, Alexander R.
kusw.kudepartment	Pharmacology & Toxicology
kusw.oastatus	fullparticipation
dc.identifier.doi	10.1128/JVI.76.4.1578-1587.2002
dc.identifier.orcid	https://orcid.org/0000-0003-2307-6035
kusw.oaversion	Scholarly/refereed, publisher version
kusw.oapolicy	This item meets KU Open Access policy criteria.
dc.rights.accessrights	openAccess

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