Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release

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Issue Date
2002-02Author
Moise, Alexander R.
Grant, Jason R.
Vitalis, Timothy Z.
Jefferies, Wilfred A.
Publisher
American Society for Microbiology
Type
Article
Article Version
Scholarly/refereed, publisher version
Metadata
Show full item recordAbstract
E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca2+ homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca2+ flux-induced and death receptor-mediated apoptosis.
Description
This is the publisher's version, also available electronically from http://jvi.asm.org/content/76/4/1578
ISSN
0022-538XCollections
- Pharmacy Scholarly Works [293]
Citation
Moise, Alexander et al. (2002). Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release. Journal of Virology 76(4):1578-1587. http://www.dx.doi.org/10.1128/JVI.76.4.1578-1587.2002
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