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Dissertations and Theses: Recent submissions
Now showing items 1881-1900 of 9900
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Examining Enrollment Barriers to Adult Cancer Clinical Trials
(University of Kansas, 2019-05-31)Advancing knowledge in cancer treatment can only be achieved with the conduct of clinical trials. Barriers to adult cancer clinical trial participation have been extensively examined, yet nearly 20% of trials fail due to ... -
Sedentary Behavior in People with Type 2 Diabetes
(University of Kansas, 2018-12-31)Sedentary behavior is a major health issue in people with type 2 diabetes (T2D). Many people with T2D are sedentary despite strong recommendations of regular physical activity. Studies that investigate the complex nature ... -
Designing an Effective Skill Learning Environment
(University of Kansas, 2018-12-31)This paper explored the dynamic process of psychomotor skill development. The design of effective skill development experiences requires the integration of a complex mosaic of interacting factors having the ultimate goal ... -
Role of Autophagy in Alcohol-induced Adipose Atrophy and Liver Injury
(University of Kansas, 2018-12-31)Alcoholic liver disease (ALD) is a worldwide health issue claiming 2 million lives per year. The pathogenesis of ALD is characterized by steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and eventually hepatocellular ... -
Role of primary cilia-mediated signaling in human and mouse models of Autosomal Dominant Polycystic Kidney Disease
(University of Kansas, 2018-12-31)Primary cilia are non-motile microtubule-based organelles that extend from the apical plasma membrane of most vertebrate cells and mediate signaling pathways. Mutations in ciliary genes often result in renal cyst formation, ... -
TRANSCRIPTOME ANALYSIS OF T CELLS IN CHROMOSOME 22Q11.2 DELETION SYNDROME
(University of Kansas, 2018-12-31)Background Phenotypic variations of chromosome 22q11.2 deletion syndrome (22qDS) have no clear explanation. T cell lymphopenia in chromosome 22q11.2 deletion syndrome (22qDS) is related to varying degrees of thymic hypoplasia ... -
Heat Shock Protein 72 Regulation of Metabolism
(University of Kansas, 2018-08-31)The prevalence of metabolic disease continues to rise in the United States, leading to conditions such as metabolic syndrome, diabetes, and NAFLD. Heat shock proteins (HSPs) are molecular chaperones which aid in protein ... -
CHARACTERIZATION OF THE MAMMALIAN METHYLTRANSFERASE TGS1
(University of Kansas, 2018-08-31)In eukaryotes, RNAs transcribed by RNA polymerase II are capped at their 5’ end. The cap is added co-transcriptionally and, in the case of mRNAs, contains one methyl group, resulting in a monomethylguanosine cap. In the ... -
Regulated assembly of a prion-like phosphatase, CG5830, controls its phosphatase activity and embryonic development in Drosophila melanogaster
(University of Kansas, 2018-08-31)Prion-like proteins can assume distinct conformational states in the same cell, and often one of these states leads to a self-assembling oligomer that can vary in physical nature. The conformational state change from ... -
Detecting Sepsis Using Sepsis-Related Organ Failure Assessment (SOFA) and an Electronic Sepsis Prompt in Intensive Care Unit Adult Patients
(University of Kansas, 2018-08-31)Sepsis is an elusive and costly syndrome that is one of the leading causes of death globally. Annually, there are approximately 19 million cases of sepsis that result in more than 5 million deaths. The Agency for Healthcare ... -
Epithelial CCR2 promotes breast cancer progression directly and indirectly thru crosstalk with microenvironment populations
(University of Kansas, 2019-05-31)Abstract The presence of immune cells within a tumor is often a good prognostic indicator, but in breast cancer the presence of tumor-promoting macrophages within the tumor predicts poor prognosis. The current model by ... -
Characterization of SPECC1L Function in Palatogenesis
(University of Kansas, 2019-05-31)Orofacial clefts are among the most common congenital birth defects, occurring in as many as 1 in 800 births worldwide. Genetic and environmental factors contribute to the complex etiology of these anomalies. SPECC1L encodes ... -
EXPRESSION PATTERNS AND ROLES OF THE IKAROS FAMILY OF TRANSCRIPTION FACTORS IN HUMAN REGULATORY T CELL DEVELOPMENT AND FUNCTION.
(University of Kansas, 2019-05-31)Regulatory T cells (Tregs) are a small subset of immune cells that are responsible for downregulating the immune response and maintaining immune tolerance. Tregs are generally defined by a high expression of the transcription ... -
A Combination of Three Synthetic Compounds Display Potent Antitumor Effects
(University of Kansas, 2018-12-31)Patients suffering from head and neck squamous cell carcinoma (HNSCC) encounter low survival while managing current aggressive therapies that cause significant morbidity. Nutraceuticals are diet-derived compounds with few ... -
The role of claudin-2 in the proximal tubule and kidney stone disease
(University of Kansas, 2018-08-31)The concentration of circulating blood calcium is vital to the function of many cellular processes. As such, it is maintained within a narrow range through the actions of gastrointestinal, bone, kidney, and endocrine ... -
Ipsilateral and concurrent breast cancer and atypical ductal hyperplasia: Does atypia also need surgical excision?
(University of Kansas, 2019-05-31)Background: Standard of care for management of ADH identified on percutaneous biopsy is surgical excision. Research efforts have focused on utilizing strict multidisciplinary review to identify patients at lowest risk for ... -
The Relationship Between Diet, Body Composition, Cardiorespiratory Fitness and Respiratory Quotient
(University of Kansas, 2019-05-31)Background: Respiratory Quotient (RQ) indicates the oxidation of fat or carbohydrate as a fuel source for the body during energy expenditure. Resting Metabolic Rate (RMR) and RQ are often determined during the same metabolic ... -
Evaluating the Effects of Implementing a Volume-Based Protocol in an ICU setting
(University of Kansas, 2019-05-31)Background: Patients in ICUs tend to have greater protein and calorie needs than other hospital populations, especially patients who cannot eat by mouth. Meeting these needs is crucial to patient recovery, yet for many ... -
IMPACT OF UNTREATED ADOLESCENT IDIOPATHIC SCOLIOSIS IN ADULTHOOD: A TEN-YEAR ANALYSIS
(University of Kansas, 2019-05-31)Title: Impact of Untreated Adolescent Idiopathic Scoliosis in Adulthood: A Ten-Year Analysis Background: Long-term studies of adolescent idiopathic scoliosis (AIS) in adulthood demonstrate most patients function well, ... -
Critical Insights: Incidents that Help and Hinder Parents’ Transition Related to Their Child’s Developmental Diagnosis
(University of Kansas, 2019-05-31)Individuals structure their lives around their expectations associated with phases of life (Becker, 1997). Starting a new job, starting a family and even dropping a child off for their first day of kindergarten are events ...