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Dissertations and Theses: Recent submissions
Now showing items 1821-1840 of 9900
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Reimagining the Human in Modern French Science Fiction
(University of Kansas, 2019-05-31)Due to human activity and technology, such as deforestation, nuclear testing, and the burning of fossil fuels, many geologists and environmentalists agree that we have entered a new geological epoch, the Anthropocene. The ... -
Imprints of Devotion: Print and the Passion in the Iberian World (1472-1598)
(University of Kansas, 2019-05-31)“Imprints of Devotion: Print and the Passion in the Iberian World (1472-1598)” takes a comparative approach to demonstrate that the printed books at the center of its chapters –La dolorosa passio del nostre redemptor ... -
Women’s Hypertension in Indonesia: The Role of Religion, Trust, and Community Involvement
(University of Kansas, 2019-05-31)Hypertension, or high blood pressure, is the leading cause of death worldwide and is a key risk factor for cardiovascular disease. Approximately three quarters of individuals living with hypertension reside in low- and ... -
Rough Forms: Autobiographical Interventions in the U.S. West, 1835-1935
(University of Kansas, 2019-05-31)Rough Forms analyzes U.S. Western autobiographies from 1835 to 1935, focusing especially on ways that Native and non-Native authors complicate settler-colonial narratives. In doing so, my project deeply engages with two ... -
Design of Intratumoral Immunostimulant Formulations
(University of Kansas, 2019-12-31)Cancer immunotherapy involves stimulation of the body’s own immune system to fight cancer. Tumors possess myriad suppressive mechanisms that facilitate evasion of the immune system. Immunotherapy aims to stimulate immune ... -
Brain delivery of BDNF and a monoclonal antibody for the treatment of neurodegenerative animal models
(University of Kansas, 2019-12-31)There are a large number of protein-based therapeutics (biologics) that are FDA approved and available on the market for a number of diseases, and the number of biologics being approved every year has tripled in the past ... -
Physicochemical stability and effector function of IgG4-Fc: impact of photo-induced chemical modification and glycosylation
(University of Kansas, 2019-12-31)Immunoglobulin gamma monoclonal antibodies are glycoproteins that have emerged as powerful and promising protein therapeutics. During the process of production, storage and transportation, exposure to ambient light is ... -
Bioenergetic Regulation of Neuronal Vacuolar-type H+- ATPase
(University of Kansas, 2019-12-31)Neuronal vacuolar-type H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to acidify intracellular organelles such as lysosomes and synaptic vesicles, creating a proton gradient by which neurotransmitters ... -
Surface Immobilization and Electrochemical Studies of Molecular Lanthanide and Actinide Complexes
(University of Kansas, 2019-05-31)Due to their unique properties and emerging applications in materials, the chemistry of the lanthanides and actinides has become a thriving area of research. While much work has been done to probe the electronic, magnetic, ... -
Timing and drivers of exhumation in the hinterland of the North American Cordillera from detrital zircon U-Pb and (U-Th)/He double-dating
(University of Kansas, 2019-12-31)The late Cretaceous to early Cenozoic hinterland of the North American Cordillera is widely recognized as an orogenic plateau. Although most studies suggest that this highland was in place by the Eocene, the timing and ... -
A Genetic Point of View: The Effects of Ancestry Testing on Racial and Ethnic Identities
(University of Kansas, 2019-08-31)The purpose of this research is to investigate how genetic ancestry tests can affect personal identity. Forty individuals from the cities of Topeka, Kansas City, and Lawrence who identified as primarily Black, White, or ... -
Hydrogeomorphic drivers of functional diversity in riverine fishes at an intercontinental scale
(University of Kansas, 2019-05-31)Functional diversity (FD) has been used as a metric to gauge the health and stability of fish communities in many different environments, but few studies have examined FD on an intercontinental scale. This study formally ... -
High supply, high demand: A unique nutrient addition decouples nitrate uptake and metabolism in a large river
(University of Kansas, 2019-05-31)Our current understanding of the relationship between nitrate (NO3-) uptake and energy cycling in rivers is primarily built on studies conducted in low-nutrient (NO3- < 1 mg-N L-1), small (discharge < 1 m3 s-1) systems. ... -
Pipelines, Protectors, and a Sense of Place: Media Representations of the Dakota Access Pipeline Protest
(University of Kansas, 2019-05-31)Indigenous resistance to the construction of the Dakota Access Pipeline (DAPL) garnered national and international media attention in 2016 as thousands gathered near the Standing Rock Sioux Reservation in protest. Increased ... -
Theoretical and Experimental Development of Bipolar Based Fluorescence Detection for Microchip Electrophoresis
(University of Kansas, 2019-05-31)Abstract Methods for the separation and detection of reactive oxygen and nitrogen species (RNOS) at the cellular level can be useful tools for the study of the biochemical mechanisms of neurodegenerative diseases. Microchip ... -
Analysis of Glycopeptides by HPLC MS and Detection of Leukemic Cells by Microfluidics using Time Delayed Integration Spectral Flow Cytometry
(University of Kansas, 2019-05-31)Protein glycosylation drives many biological processes and serves as marker for disease; therefore, the development of tools to study glycosylation is an essential and growing area of research. Mass spectrometry can be ... -
Evaluating Reasonableness Tests for Longitudinal Measurement Invariance in Structural Equation Modeling using Confirmatory Factor Analysis
(University of Kansas, 2019-05-31)Researchers are typically interested in comparing groups of people and/or comparing people across time. If researchers are to conclude differences are due to group dynamics or time, we must establish that the measure(s) ... -
Activation and Inhibition of Biological Function through Design of Novel Protein-Ligand Interactions
(University of Kansas, 2019-05-31)Virtually every process within a cell involves a protein. They serve as cellular workhorses carrying out functions such as catalysis of essential metabolites, to regulating which genes get turned on or off, to forming the ... -
Analysis of Spa33 and its Role in T3SS Cytoplasmic Sorting Platform of Shigella
(University of Kansas, 2019-12-31)Enteric infections, particularly those leading to diarrhea, can profoundly disrupt intestinal function and have a major impact on global mortality and morbidity rates.1 Globally, there are 1.7 billion cases of childhood ... -
Preservation of Human T Cell Membrane Integrity after Drying and Rehydration
(University of Kansas, 2019-12-31)The biopharmaceutical industry has reached new frontiers in its ability to produce complex novel modalities for therapeutic application. Novel cell-based therapies offer a promising treatment for cancer by enabling T cells ...