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dc.contributor.authorZeng, Yong
dc.contributor.authorShin, Mimi
dc.contributor.authorWang, Tanyu
dc.identifier.citationZeng, Yong; Shin, Mimi; and Wang, Tanyu. (2013) Programmable active droplet generation enabled by integrated pneumatic micropumps. Lab on a Chip, 13, 267.
dc.descriptionA grant from the One-University Open Access Fund at the University of Kansas was used to defray the author’s publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of the Provost, Dr. Jeffrey Vitter; Vice Chancellor for Research & Graduate Studies, Dr. Steve Warren; Acting KUMC Executive Vice Chancellor, Dr. Steve Stites; and Dr. Paul Terranova, KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see This journal is The Royal Society of Chemistry 2013. When the author signs the exclusive Licence to Publish for a journal article, he/she retains certain rights that may be exercised without reference to the RSC. He/she may:

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dc.description.abstractIn this work we have investigated the integrated diaphragm micropump as an active fluidic control approach for the on-demand generation of droplets with precisely defined size, frequency and timing. In contrast to valve-actuated devices that only modulate the flow of the dispersed phase being continuously injected, this integrated micropump allows the combination of fluidic transport and modulation to achieve active control of droplet generation. A distinct characteristic of this method compared to the valve modulated droplet formation processes is that it enables independent control of droplet generation frequency by adjusting the pumping frequency and droplet size by flow conditions. We also demonstrated the generation of complex droplet patterns through programming the pumping configurations and the application to multi-volume digital PCR for precise and quantitative detection of genetic targets. Overall, our results suggest that the pump-based droplet microfluidics provide a robust platform for programmable active droplet generation which could facilitate the development of high-performance chemical and biological assays.
dc.publisherRSC Publishing
dc.titleProgrammable active droplet generation enabled by integrated pneumatic micropumps
kusw.kuauthorZeng, Yong
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.

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