ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Medicinal Chemistry Scholarly Works: Recent submissions
Now showing items 201-220 of 255
-
Cytotoxic Oleanane-Type Saponins from Albizia inundata
(Journal of Natural Products, 2011-02-11)Bioassay-guided fractionation of a CH2Cl2−MeOH extract of the aerial parts of Albizia inundata resulted in the isolation of two new natural oleanane-type triterpene saponins {3-O-[α-l-arabinopyranosyl(1→6)]-2-acetamido-2 ... -
Application of Phase-Trafficking Methods to Natural Products Research
(Journal of Natural Products, 2010-08-12)A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. ... -
Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes
(Thieme Publishing, 2015-01-01)Fluorinated fluorophores are valuable tools for studies of biological systems. However, amine-reactive single-isomer derivatives of these compounds are often very expensive. To provide an inexpensive alternative, we report ... -
Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates
(Thieme Publishing, 2015-07-15)The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl ... -
c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells
(Elsevier, 2015-08-11)The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity, tailoring the chaperone function to specific “client” proteins. ... -
Graphene/GaSe-Nanosheet Hybrid: Towards High Gain and Fast Photoresponse
(Public Library of Science, 2016-01-18) -
A Systematic Protocol for the Characterization of Hsp90 Modulators
(Elsevier, 2010-10-19)Several Hsp90 modulators have been identified including the N-terminal ligand geldanamycin (GDA), the C-terminal ligand novobiocin (NB), and the co-chaperone disruptor celastrol. Other Hsp90 modulators elicit a mechanism ... -
Graphene/GaSe-Nanosheet Hybrid: Towards High Gain and Fast Photoresponse
(Nature Publishing Group, 2016-01-18)While high photoconductive gain has been recently achieved in graphene-based hybrid phototransistors using semiconductor two-dimensional transition/post-transition metal dichalcogenides or quantum dots sensitizers, obtaining ... -
An update on plague
(Current Science Association, 1994) -
Induction of Heat Shock Protein 70 (Hsp70) prevents Neuregulin-Induced Demyelination by Enhancing the Proteasomal Clearance of c-Jun
(SAGE, 2012-11-01)Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, DPN (diabetic peripheral neuropathy) and possibly, demyelinating neuropathies. ... -
Cyclization of a carbon-centered radical derived from oxaziridine cleavage
(Michigan Publishing, 2006)Treatment of an oxaziridine with low-valent iron or copper salts generates a carbon-centered radical able to cyclize onto an appended olefin. -
Lipopolyamines: Novel Antiendotoxin Compounds That Reduce Mortality in Experimental Sepsis Caused by Gram-Negative Bacteria
(The American Society for Microbiology, 1999-04)The interactions of lipopolyamines, a class of structurally unique compounds currently being used as transfection (lipofection) agents, with lipopolysaccharide (LPS) have been characterized. Our studies have demonstrated ... -
Oxidative Modifications of Kynostatin-272, a Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor: Potential Mechanism for Altered Activity in Monocytes/Macrophages
(The American Society for Microbiology, 2002-02)Previous studies have indicated that human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) are less active at blocking viral replication in HIV-1 infected peripheral blood monocytes/macrophages (M/M) than ... -
Structural Correlates of Antibacterial and Membrane-Permeabilizing Activities in Acylpolyamines
(The American Society for Microbiology, 2006-03)A homologous series of mono- and bis-acyl polyamines with varying acyl chain lengths originally synthesized for the purpose of sequestering lipopolysaccharide were evaluated for antimicrobial activity to test the hypothesis ... -
Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant
(The American Society for Microbiology, 2007-08)Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to ... -
Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues
(The American Society for Microbiology, 2008-03)RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have ... -
Structure-Activity Relationships of Antimicrobial and Lipoteichoic Acid-Sequestering Properties in Polyamine Sulfonamides
(The American Society for Microbiology, 2009-01)We have recently confirmed that lipoteichoic acid (LTA), a major constituent of the gram-positive bacterial surface, is the endotoxin of gram-positive bacteria that induces proinflammatory molecules in a Toll-like receptor ... -
(ÿ)-Fern-7-en-3a-ol from Sebastiania brasiliensis
(International Union of Crystallography, 2003)The structure of a fernane isolated from S. brasiliensis was established as fern-7en-3[alpha]-ol, C30H50O. Rings A and D assume a chair conformation, while rings B and C adopt a twist-boat conformation. Rings A/B, C/D, and ... -
Crystallization of PNMT, the adrenalinesynthesizing enzyme, is critically dependent on a high protein concentraition
(International Union of Crystallography, 2001)Phenylethanolamine N-methyltransferase, PNMT, utilizes the methylating cofactor S-adenosyl-L-methionine to catalyse the synthesis of adrenaline. Human PNMT has been crystallized in complex with an inhibitor and the cofactor ... -
Tarapacol 15-Acetate, a New Diterpenoid from Grindelia tarapacana Phil.
(International Union of Crystallography, 1996)In the title compound, 15-acetoxy-14(S)-hydroxy-13-epi-manoyl oxide {IUPAC systematic name: 2-(dodecahydro-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-3-yl)-2-hydroxyethyl acetate}, C22H38N4, rings A and B have chair ...