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How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data
Crawford, Michael H. ; Fagundes, Nelson J. R. ; Tagliani-Ribeiro, Alice ; Rubicz, Rohina ; Tarskaia, Larissa ; Salzano, Francisco M. ; Bonatto, Sandro L.
Crawford, Michael H.
Fagundes, Nelson J. R.
Tagliani-Ribeiro, Alice
Rubicz, Rohina
Tarskaia, Larissa
Salzano, Francisco M.
Bonatto, Sandro L.
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Abstract
In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus
has emerged about important parameters such as the effective size of the Native Americans founder population.
Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from
Latino populations, while other recent studies using samples from Native American individuals relied on approximated
analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native
American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting
for recent flow between Asian and Native American populations. Our results suggest that, in agreement
with previous studies, the effective size of the Native American population was small, most likely in the order of a few
hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as
large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important
for determining the extent of genetic markers needed to characterize Native American populations in genome-wide
studies and to evaluate the adaptive potential of genetic variants in this population.
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Date
2018-01-01
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Sociedade Brasileira de Genética
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Keywords
Isolation with Migration model, Coalescent analysis, Native Siberians
Citation
Fagundes, Nelson J.R., Tagliani-Ribeiro, Alice, Rubicz, Rohina, Tarskaia, Larissa, Crawford, Michael H., Salzano, Francisco M., & Bonatto, Sandro L.. (2018). How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data. Genetics and Molecular Biology, 41(1, Suppl. 1), 206-214. https://dx.doi.org/10.1590/1678-4685-gmb-2017-0087