KU ScholarWorks
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Publication Course-Based Research Assignment: Algorithms for High-Performance Computing (EECS 690)(2025-05-09)This assignment was created for EECS 690: Algorithms for HPC, which is a senior elective class, and at the same time offered to graduate students. Students were asked to conduct a research project spanning half a semester on a selected topic in high-performance computing (HPC). The topic could be of theoretical or empirical nature, or a combination of both. The objective is to get students familiar with the process of conducting academic research, have students develop critical thinking, creativity, and problem-solving skills, and promote an understanding of research methodology. The project consists of five weeks of intense research activities, with each week achieving a specific milestone of the research cycle. After conducting the research, students wrote a project report and presented the findings to the class and at the 2025 Spring Undergraduate Research Symposium hosted by the Center for Undergraduate Research & Fellowships (CURF) at The University of Kansas.Publication Characterizing the Aggregation Propensity of an Anti-HIV-1 Bispecific Antibody in Two Different Formulation Buffers During Agitation Stress (Dataset)(University of Kansas, 2025)There is growing interest in administering bispecific, broadly neutralizing antibodies as a therapeutic strategy to control and prevent HIV-1 infection. Bispecific antibody (BsAb) candidates can be challenging to formulate as stable dosage forms since they are generally more prone to aggregation compared to widely commercialized monospecific monoclonal antibodies (mAbs). The anti-HIV-1 bispecific antibody 10E8.4/iMab is a promising BsAb candidate in clinical trials that is designed to block HIV-1 viral entry into cells. During initial formulation development, visible particles were observed upon storage under certain conditions. In this case study, we evaluated the physical stability of 10E8.4/iMab to better understand the aggregation and particle formation profiles before and after exposure to agitation stress. First, key structural attributes of the unstressed BsAb were determined including primary and higher-order structure, size, and conformational stability. Second, a combination of analytical methods was used to monitor the formation of soluble aggregates, subvisible particles, and visible particulates during agitation studies in Buffer 1 containing a salt (20 mM NaAc, 100 mM NaCl, pH 5.5) and Buffer 2 containing a sugar and a nonionic surfactant (20 mM NaAc, 6.5% sucrose, 0.02% PS80, pH 5.5 . Third, the particulates generated during agitation of 10E8.4/iMab in Buffer 1 were shown to contain structurally altered protein. It was observed that Buffer 2 not only minimized aggregation and particle formation during agitation but also increased the conformational stability of the BsAb compared to Buffer 1. The results from this case study are discussed in the context of enabling future developability and formulation studies with other aggregation-prone BsAb candidates.Publication Acute effects of lower limb wearable resistance on horizontal deceleration and change of direction biomechanics(Public Library of Science (PLoS), 2024-9-9)This study aimed to investigate the acute effects of lower limb wearable resistance on maximal horizontal deceleration biomechanics, across two different assessments. Twenty recreationally trained team sport athletes performed acceleration to deceleration assessments (ADA), and 5-0-5 change of direction (COD) tests across three load conditions (unloaded, 2% of BW, 4% of body weight (BW)), with load attached to the anterior and posterior thighs and shanks. Linear mixed effect models with participant ID as the random effect, and load condition as the fixed effect were used to study load-specific biomechanical differences in deceleration mechanics across both tests. Primary study findings indicate that for the ADA, in the 4% BW condition, participants exhibited significantly greater degrees of Avg Approach Momentum, as well as significant reductions in deceleration phase center of mass (COM) drop, and Avg Brake Step ground contact deceleration (GCD) in both the 2% BW, and 4% BW condition, compared to the unloaded condition. In the 5-0-5 tests, participants experienced significant reductions in Avg Approach Velocity, Avg deceleration (DEC), and Stopping Time in the 4% BW condition compared to the unloaded condition. Similar to the ADA test, participants also experienced significant reductions in Avg Brake Step GCD in both the 2% BW and 4% BW conditions, and significant increases in Avg Approach Momentum in the 4% BW condition, compared to the unloaded condition. Therefore, findings suggest that based on the test, and metric of interest, the addition of lower limb wearable resistance led to acute differences in maximal horizontal deceleration biomechanics. However, future investigations are warranted to further explore if the use of lower limb wearable resistance could present as an effective training tool in enhancing athlete's horizontal deceleration and change of direction performance.Publication Comparing the maximal horizontal deceleration demands between a novel acceleration to deceleration assessment and the 505 change of direction test(Asociacion Espanola de Analisis del Rendimiento Deportivo, 2024-4-23)The importance of quantifying maximal horizontal deceleration performance in athlete populations has received a considerable increase in interest over recent years. However, research is still scarce investigating movement characteristics of maximal horizontal decelerations outside of measures derived from instantaneous horizontal velocity of the centre of mass, using technologies such as radar or laser-based devices. Therefore, this study aimed to explore the biomechanical differences for measures of deceleration ability between a novel deceleration task, and the 505 change of direction test, using an inertial measurement unit-based technology. Primary findings suggested differences across several biomechanical characteristics quantified during the deceleration phase, with moderate to large between-test effect sizes. Specifically, subjects were found to exhibit significantly greater reductions in velocity and horizontal braking forces in the 505. Further, subjects showed significantly shorter stopping times and distances in the acceleration-deceleration assessment, however, these displayed insufficient levels of reliability across both assessments, which should be interpreted as a limitation. Therefore, it may be speculated that based on our data, the 505 test, which possesses a predetermined stopping/turning point, presents a greater or different biomechanical challenge to individuals, which must be met with the appropriate neuromuscular and skill-related qualities to efficiently reduce whole-body momentum. These findings may be relevant to practitioners interested in choosing the right assessment to quantify athletes’ maximal horizontal deceleration performance, which can have implications for both health and performance.Publication Differences in countermovement vertical jump force-time metrics between starting and non-starting professional male basketball players(Frontiers Media SA, 2023-12-8)With force plates being widely implemented for neuromuscular performance assessment in sport-specific settings and various force-time metrics being able to differentiate athletes based on their performance capabilities, the purpose of the present study was to examine the differences in countermovement vertical jump (CVJ) characteristics between starting and non-starting professional male basketball players (e.g., ABA League). Twenty-three athletes (height = 199.2 ± 7.7 kg, body mass = 94.2 ± 8.2 kg, age = 23.8 ± 4.9 years) volunteered to participate in the present investigation. Upon completion of a standardized warm-up protocol, each athlete performed three maximal-effort CVJs without an arm swing while standing on a uni-axial force plate system sampling at 1,000 Hz. Independent t-tests were used to examine statistically significant differences (p < 0.05) in each force-time metric between starters (n = 10) and non-starters (n = 13). No significant differences in any of the CVJ force-time metrics of interest were observed between the two groups, during both the eccentric and concentric phases of the movement (i.e., impulse, duration, peak velocity, and mean and peak force and power). Moreover, starters and non-starters demonstrated similar performance on CVJ outcome (e.g., jump height) and strategy metrics (e.g., countermovement depth). Overall, these findings suggest that at the professional level of play, the ability to secure a spot in the starting lineup is not primarily determined by the players' CVJ performance characteristics.