KU ScholarWorks

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Recent Submissions

Characterization of M11-like and OC125-like monoclonal antibody binding to CA125 tandem repeats (Dataset)
(2025-08-22) McNair, Trisha; McEntee, Caitlin R.; Wang, Chien-Wei; Srivastiva, Anubhuti; March , Jane C.; Hanson, Eliza; Whelan, Rebecca
The CA125 epitope within the MUC16 tandem repeat region is detected via the CA125 II test for ovarian cancer surveillance. This test utilizes the M11 and OC125 antibodies. A revised model of MUC16 with 19 tandem repeats has recently been identified, including splice variants that exclude entire repeats. Additionally, OC125 has exhibited gaps in coverage of the tandem repeat region. To identify antibodies that bind more repeats and are suitable for spliceoform detection, more antibodies must be characterized using the revised model. This study characterized the binding of two M11-like and two OC125-like antibodies against the updated tandem repeat numbering system. 16 individual tandem repeats were expressed and purified. Binding interactions between each of the antibodies and recombinant repeats were examined by indirect enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR). The M11-like antibodies displayed different binding patterns when compared to each other, while the two OC125-like antibodies exhibited similar binding patterns. M11-like clone M77161 bound to all 16 repeats tested, indicating that it may be suitable for accurate detection of CA125. These findings demonstrate how different antibodies vary in their binding to CA125, contributing to ongoing development of improved clinical and research tools for ovarian cancer.
The Sticky Side of Sugar, Spice, and Everything Nice: Quantifying the Binding of Li+ to Triphenylphosphine Oxide (TPPO) with 7Li and 31P NMR and Volatile and Particulate Emissions from Home 3D Printers
(Department of Chemistry, University of Kansas, 2025-05-16) Thach, Colleen Lee
The behavior of lithium cations in nonaqueous solvents influences the performance of lithium-ion batteries; however few measurements have systematically and quantitatively examined the properties of lithium salts in nonaqueous solvents. Results from nuclear magnetic resonance studies designed to interrogate the properties of lithium salt species in the nonaqueous solvents acetonitrile, propylene carbonate, and tetrahydrofuran are presented in the first chapter of this thesis. A suite of lithium-7 and phosphorus-31 spectral data have been collected to study the interactions of lithium cations with a model ligand, triphenylphosphine oxide (TPPO), by titration methods. Our results reveal that the Li-7 chemical shift is dependent on the concentration of added TPPO; however, the equilibria measured for binding of TPPO depend on the nucleus being interrogated, Li-7 or P-31 respectively, a phenomenon attributable to the titration conditions and ratio of reagents used in the titration studies interrogating each element. Ligand binding and solvent effects are discussed, including comparisons between the solution behaviors of various lithium salts. Taken together, current results suggest that both solvent and lithium counteranion identity impact the speciation in nonaqueous solvents. Additionally, the concentrations of lithium and TPPO (as well as the ratio of these concentrations) strongly influence the quantitative data resulting from individual titrations, underscoring the uniqueness of the individual measurements on closely related sets of solution conditions. The rapid expansion of 3D printing technologies has led to increased utilization in various industries and has also become pervasive in the home environment. Although the benefits are well acknowledged, concerns have arisen regarding potential health and safety hazards associated with emissions of volatile organic compounds (VOCs) and particulates during the 3D printing process. The home environment is particularly hazardous given the lack of health and safety awareness of the typical home user. The study presented in the second chapter of this thesis aims to assess the safety aspects of 3D printing of PLA and ABS filaments by investigating emissions of VOCs and particulates, characterizing their chemical and physical profiles, and evaluating potential health risks. Gas chromatography–mass spectrometry (GC–MS) was employed to profile VOC emissions, while a particle analyzer (WIBS) was used to quantify and characterize particulate emissions. Our research highlights that 3D printing processes release a wide range of VOCs, including straight and branched alkanes, benzenes, and aldehydes. Emission profiles depend on filament type but also, importantly, the brand of filament. The size, shape, and fluorescent characteristics of particle emissions were characterized for PLA-based printing emissions and found to vary depending on the filament employed. This is the first 3D printing study employing WIBS for particulate characterization, and distinct sizes and shape profiles that differ from other ambient WIBS studies were observed. The findings emphasize the importance of implementing safety measures in all 3D printing environments, including the home, such as improved ventilation, thermoplastic material, and brand selection. Additionally, our research highlights the need for further regulatory guidelines to ensure the safe use of 3D printing technologies, particularly in the home setting.
Perceptual regions of Lawrence, Kansas
(University of Kansas, 1985-05-31) Schmiedeler, Tom
This study examines perceptual regions in Lawrence, Kansas. Data were collected in field interviews of residents. Characteristics of seven of the most highly perceived regions are discussed at length. Perceptual regions should have practical application for city planners and urban agencies, since these areas serve as measures of social and geographical realities for local folk. For urban perceptual regions to have practical application as a city's functioning units, however, the time and expense of data acquisition must be reduced. One possible surrogate measure, mean family income, readily available from the Census Bureau, is studied here. Perceptual regions do exist in Lawrence according to my survey, and mean family income is a useful surrogate for them. Underlying themes associated with perceptual regions include the influence of physical geography, major thoroughfares, and historic cores on the selection of area characteristics and boundaries; the identification of cultural roots through the contemporary landscape; and cultural dichotomy expressed in contrasting attitudes toward preservation and development.
THE ADAPTIVE MONUMENT: AUTHENTICITY AND ADAPTATION IN NOTRE-DAME’S POST-FIRE REVIVAL
(Department of History, University of Kansas, 2025-04-29) Watt, Ivy
The 2019 Notre-Dame Cathedral fire ignited critical debates about architectural preservation and authenticity. This research examines how preservation theory evolved from 19th-century Romantic ideals to modern international standards, particularly those established by UNESCO and ICOMOS, tracing the influential contributions of four key theorists: French architect Eugène Viollet-le-Duc's interventionist approach, English critic John Ruskin's conservationist philosophy, Italian architect Camillo Boito's scientific methods, and Austrian art historian Alois Riegl's value-based framework. This evolution in preservation theory marks a transition from pursuing idealized historical appearances to understanding monuments as carriers of accumulated cultural meaning through time, informing contemporary preservation approaches. Through comparative analysis of Notre-Dame's successive restorations, this study uses historical records, preservation charters, and modern media to trace the cathedral's architectural history and theoretical debates, challenging the perceived conflict between innovation and tradition in preservation theory. The cathedral that burned in 2019 was already a testament to centuries of architectural adaptation, where each era's modifications preserved and transformed the structure. The current restoration, integrating traditional craftsmanship with modern technology, demonstrates how these seemingly opposing forces have always coexisted in architectural preservation. This research contributes to ongoing discussions about authenticity in historic preservation, offering a framework for future restoration projects facing modern challenges like climate change and disaster prevention.
NEGOTIATING A HYBRID JAPANESE AMERICAN IDENTITY: AN ANALYSIS OF CULTURAL CELEBRATIONS IN INTERNMENT CAMP NEWSPAPERS
(Department of History, University of Kansas, 2025-05-02) Schumaker, Nataley R.
On February 19, 1942, two months after the Japanese attack on Pearl Harbor, United States President Franklin D. Roosevelt issued Executive Order 9066, authorizing the forced removal of people of Japanese descent from their homes along the West Coast to internment camps located further inland. Scholars estimate the United States incarcerated approximately 120,000 from 1942 to 1945. In 1942 the War Relocation Authority (WRA) was established to run the internment camps and regulate daily life within the camps. Specifically, the WRA required the internment camps to publish a newspaper publication that detailed news directly from the WRA but was also used to spread information about upcoming events to the community. I investigated the newspapers from three camps: Rohwer in McGehee, Arkansas; Granada in Amache, Colorado; and Topaz in Topaz, Utah. Japanese American editors published news articles of cultural events, celebrations, and festivals throughout their internment. During their internment, Japanese Americans demonstrated their loyalty as people of Japanese descent in the United States. Yet, at the same time, they found ways to celebrate their Japanese identity. I argue that Japanese Americans in internment camps strategically used both Japanese and American forms of cultural celebration to assert their right to a hybrid identity, despite government attempts to question their loyalty. My primary source research and analysis fills a gap in scholarly work on Japanese American internment camps by using direct examples of celebrations from the newspapers and addressing a Japanese American hybrid identity that was solidified during internment.