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KU ScholarWorks: Recent submissions
Now showing items 701-720 of 29499
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With Plenty of Elbow Room: Planning New and Upgraded Spaces for Library and Archives Conservation and Audiovisual Preservation
(Sage, 2021-12)In 2018, the University of Kansas (KU) Libraries upgraded from a tired, twenty-year-old basement space to a new, purpose-built conservation lab for library and archives collections. The new conservation lab, which is housed ... -
Ligand Gaussian Accelerated Molecular Dynamics 2 (LiGaMD2): Improved Calculations of Ligand Binding Thermodynamics and Kinetics with Closed Protein Pocket
(American Chemical Society, 2023-01-27)Ligand binding thermodynamics and kinetics are critical parameters for drug design. However, it has proven challenging to efficiently predict ligand binding thermodynamics and kinetics from molecular simulations due to ... -
Returning to the Financial Services Workforce after an Extended Child-Rearing Leave: A Descriptive Study Regarding the Influence of Mentorship on Feelings of Identity and Self-Efficacy
(Hilaris SRL, 2023-05-20)Objectives: To explore the experiences of women in the United States that have returned to the financial services workforce after an extended child-rearing leave and their descriptions of the transition back to the workforce, ... -
Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system
(Springer, 2022-01-08)Rationale Adverse psychosocial factors during early childhood or adolescence compromise neural structure and brain function, inducing susceptibility for many psychiatric disorders such as substance use disorder. Nevertheless, ... -
Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens
(Elsevier, 2023-03-14)Opioid use disorder (OUD) is a chronic disease characterized by compulsive opioid taking and seeking, affecting millions of people worldwide. The high relapse rate is one of the biggest challenges in treating opioid ... -
Clinical and neurocognitive issues associated with Bosch-Boonstra-Schaaf optic atrophy syndrome: A case study
(Wiley, 2019-11-15)Nuclear receptor subfamily 2 group F member 1 (NR2F1) is an orphan receptor and transcriptional regulator that is involved in neurogenesis, visual processing and development, and cortical patterning. Alterations in NR2F1 ... -
Ring Opening of Aziridines by Pendant Silanols Allows for Stereospecific Preparations of 1′-Amino-tetrahydrofurans
(American Chemical Society, 2023-05-30)We have developed a highly stereospecific cyclization of aziridine silanols into 1′-amino-tetrahydrofurans. Our protocol of stirring a substrate with 10 mol % Sc (OTf)3 and 1 equivalent of NaHCO3 in CH2Cl2 is mild and ... -
Insulin-like growth factor 1 regulates excitatory synaptic transmission in pyramidal neurons from adult prefrontal cortex
(Elsevier, 2022-10-01)Insulin-like growth factor 1 (IGF1) influences synaptic function in addition to its role in brain development and aging. Although the expression levels of IGF1 and IGF1 receptor (IGF1R) peak during development and decline ... -
Deep Boosted Molecular Dynamics: Accelerating Molecular Simulations with Gaussian Boost Potentials Generated Using Probabilistic Bayesian Deep Neural Network
(American Chemical Society, 2023-05-23)We have developed a new deep boosted molecular dynamics (DBMD) method. Probabilistic Bayesian neural network models were implemented to construct boost potentials that exhibit Gaussian distribution with minimized anharmonicity, ... -
Critical Non-Covalent Binding Intermediate for an Allosteric Covalent Inhibitor of SUMO E1
(American Chemical Society, 2023-03-10)Post-translational modifications by small ubiquitin-like modifiers (SUMOs) are dysregulated in many types of cancers. The SUMO E1 enzyme has recently been suggested as a new immuno-oncology target. COH000 was recently ... -
In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles
(Wiley, 2022-06-14)We report an in-plane extended nanopore Coulter counter (XnCC) chip fabricated in a thermoplastic via imprinting. The fabrication of the sensor utilized both photolithography and focused ion beam milling to make the ... -
Distinguishing academic science writing from humans or ChatGPT with over 99% accuracy using off-the-shelf machine learning tools
(Elsevier, 2023-06-21)ChatGPT has enabled access to artificial intelligence (AI)-generated writing for the masses, initiating a culture shift in the way people work, learn, and write. The need to discriminate human writing from AI is now both ... -
Measurement of the differential tt⎯⎯ production cross section as a function of the jet mass and extraction of the top quark mass in hadronic decays of boosted top quarks
(Elsevier, 2023-07-03)A measurement of the jet mass distribution in hadronic decays of Lorentz-boosted top quarks is presented. The measurement is performed in the lepton + jets channel of top quark pair production (tt⎯⎯) events, where the ... -
Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae
(Elsevier, 2023-09)The International Committee on Systematics of Prokaryotes (ICSP) discussed and rejected in 2020 a proposal to modify the International Code of Nomenclature of Prokaryotes to allow the use of gene sequences as type for ... -
CMS PYTHIA 8 colour reconnection tunes based on underlying-event data
(SpringerOpen, 2023-07-10)New sets of parameter tunes for two of the colour reconnection models, quantum chromodynamics-inspired and gluon-move, implemented in the PYTHIA 8 event generator, are obtained based on the default CMS PYTHIA 8 ... -
Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines (Dataset)
(Elsevier, 2023-08-16)The development of safe and effective second-generation COVID-19 vaccines to improve affordability and storage stability requirements remains a high priority to expand global coverage. In this report, we describe formulation ... -
Coevolution of the Tlx homeobox gene with medusa development (Cnidaria: Medusozoa)
(Nature Research, 2023-07-11)Cnidarians display a wide diversity of life cycles. Among the main cnidarian clades, only Medusozoa possesses a swimming life cycle stage called the medusa, alternating with a benthic polyp stage. The medusa stage was ... -
Evaluation of AlphaFold-Multimer prediction on multi-chain protein complexes
(Oxford University Press, 2023-07-05)Motivation Despite near-experimental accuracy on single-chain predictions, there is still scope for improvement among multimeric predictions. Methods like AlphaFold-Multimer and FoldDock can accurately model dimers. ... -
Repeat sprint fatigue and altered neuromuscular performance in recreationally trained basketball players
(Public Library of Science, 2023-07-17)The primary aim of the present study was to investigate how the fatigue induced through a repeat sprint protocol acutely affected different measures of neuromuscular performance. Recreationally trained basketball players ... -
Identification of a novel transport system in Borrelia burgdorferi that links the inner and outer membranes
(Pathogens and Disease, 2023-06-29)Borrelia burgdorferi, the spirochete that causes Lyme disease, is a diderm organism that is similar to Gram-negative organisms in that it contains both an inner and outer membrane. Unlike typical Gram-negative organisms, ...