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KU ScholarWorks: Recent submissions
Now showing items 1081-1100 of 29499
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Exploring individual differences in musical rhythm and grammar skills in school-aged children with typically developing language
(Nature Research, 2023-02-07)A growing number of studies have shown a connection between rhythmic processing and language skill. It has been proposed that domain-general rhythm abilities might help children to tap into the rhythm of speech (prosody), ... -
High acoustic diversity and behavioral complexity of katydids in the Mesozoic soundscape
(National Academy of Sciences, 2022-12-15)Acoustic communication has played a key role in the evolution of a wide variety of vertebrates and insects. However, the reconstruction of ancient acoustic signals is challenging due to the extreme rarity of fossilized ... -
Protein folds vs. protein folding: Differing questions, different challenges
(National Academy of Sciences, 2022-12-29) -
Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease
(MDPI, 2023-01-25)Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset Alzheimer’s disease (LOAD), whereas ApoE2 reduces the risk for LOAD. The underlying mechanisms are unclear but may include effects on brain ... -
Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons
(MDPI, 2023-02-02)Herpes simplex virus 1 (HSV-1) enters sensory neurons with the potential for productive or latent infection. For either outcome, HSV-1 must curtail the intrinsic immune response, regulate viral gene expression, and remove ... -
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
(Nature Research, 2023-02-14)Presenilin-1 (PS1) is the catalytic subunit of γ-secretase which cleaves within the transmembrane domain of over 150 peptide substrates. Dominant missense mutations in PS1 cause early-onset familial Alzheimer’s disease ... -
Towards a structurally resolved human protein interaction network
(Nature Research, 2023-01-23)Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of ... -
Ethnodemographic characterization of stroke incidence and burden of disease in hospital discharge records in Ecuador
(Frontiers Media, 2023-02-08)Introduction: Stroke is the second most common cause of death and disability-adjusted life years (DALYs) globally. However, the incidence and impact of stroke by ethnicity and gender is frequently distinct. This is ... -
Early Release Science of the exoplanet WASP-39b with JWST NIRISS
(Nature Research, 2023-01-09)The Saturn-mass exoplanet WASP-39b has been the subject of extensive efforts to determine its atmospheric properties using transmission spectroscopy1,2,3,4. However, these efforts have been hampered by modelling degeneracies ... -
Early Release Science of the exoplanet WASP-39b with JWST NIRSpec G395H
(Nature Research, 2023-01-09)Measuring the abundances of carbon and oxygen in exoplanet atmospheres is considered a crucial avenue for unlocking the formation and evolution of exoplanetary systems1,2. Access to the chemical inventory of an exoplanet ... -
Rethinking the time spent at school: Could flexibility improve engagement and performance for students and teachers?
(Springer, 2023-05-03)Is it possible to reduce the time students spend in classrooms and schools? Would such a reduction be better for learning and retaining teachers? How should learning be more flexibly enacted in the post-pandemic era? This ... -
Development of an In Vitro System To Emulate an In Vivo Subcutaneous Environment: Small Molecule Drug Assessment
(American Chemical Society, 2022-10-24)A reliable in vitro system can support and guide the development of subcutaneous (SC) drug products. Although several in vitro systems have been developed, they have some limitations, which may hinder them from getting ... -
Choices between money and hyper-palatable food: Choice impulsivity and eating behavior
(American Psychological Association, 2022-08)Objective: Choice impulsivity may influence eating behavior. The study tested whether choice impulsivity, termed delay discounting, may be related to food generally, or may be specific to hyper-palatable foods (HPF). The ... -
Separation and Detection of Tyrosine and Phenylalanine-derived Oxidative Stress Biomarkers Using Microchip Electrophoresis with Electrochemical Detection
(Wiley, 2021-12-31)A method for the determination of selected aromatic amino acid biomarkers of oxidative stress using microchip electrophoresis with electrochemical detection is described. The separation of the major reaction products of ... -
Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)
(Springer, 2023-03-22)We recently developed an in vitro testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ... -
N-arylated oxathiazinane heterocycles are convenient synthons for 1,3-amino ethers and 1,3-amino thioethers
(Springer, 2020-05-17)This communication describes a variety of nucleophilic ring openings of N-arylated oxathiazinane heterocycles. We find that this reaction is compatible with phenoxides, naphthoxides, and thiolates and allows for the rapid ... -
What constitutes a community? A co-occurrence exploration of the Costa Rican avifauna
(Taylor and Francis, 2023-04-27)The concept of a “community” as a form of organization for natural biological systems is both widespread and widely accepted within the ecological and biological sciences. Communities have been defined as groups of organisms ... -
The HRA2pl fusion peptide exerts in vitro antiviral activity against human respiratory paramyxoviruses and pneumoviruses
(Frontiers Media, 2023-04-20)Acute respiratory infections are a group of diseases caused by viruses, bacteria, and parasites that mainly affect children until the age of 5 and immunocompromised senior adults. In Mexico, these infections are the main ... -
Transmission risk of Oropouche fever across the Americas
(BMC, 2023-05-06)Background Vector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic impacts. Oropouche ... -
Crystal orientation fabric anisotropy causes directional hardening of the Northeast Greenland Ice Stream
(Nature Research, 2023-05-08)The dynamic mass loss of ice sheets constitutes one of the biggest uncertainties in projections of ice-sheet evolution. One central, understudied aspect of ice flow is how the bulk orientation of the crystal orientation ...