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    Software for supporting large scale data processing for High Throughput Screening

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    Tai_ku_0099M_11885_DATA_1.pdf (1.587Mb)
    Issue Date
    2011-12-31
    Author
    Tai, David
    Publisher
    University of Kansas
    Format
    73 pages
    Type
    Thesis
    Degree Level
    M.E.
    Discipline
    Electrical Engineering & Computer Science
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    High Throughput Screening for is a valuable data generation technique for data driven knowledge discovery. Because the rate of data generation is so great, it is a challenge to cope with the demands of post experiment data analysis. This thesis presents three software solutions that I implemented in an attempt to alleviate this problem. The first is K-Screen, a Laboratory Information Management System designed to handle and visualize large High Throughput Screening datasets. K-Screen is being successfully used by the University of Kansas High Throughput Screening Laboratory to better organize and visualize their data. The next two algorithms are designed to accelerate the search times for chemical similarity searches using 1-dimensional fingerprints. The first algorithm balances information content in bit strings to attempt to find more optimal ordering and segmentation patterns for chemical fingerprints. The second algorithm eliminates redundant pruning calculations for large batch chemical similarity searches and shows a 250% improvement for the fastest current fingerprint search algorithm for large batch queries.
    URI
    http://hdl.handle.net/1808/9705
    Collections
    • Engineering Dissertations and Theses [1055]
    • Theses [3827]

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    785-864-8983
    KU Libraries
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    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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