Development of libraries inspired by sparteine
Issue Date
2011-21-31Author
Singh, Gurpreet
Publisher
University of Kansas
Format
70 pages
Type
Thesis
Degree Level
M.S.
Discipline
Medicinal Chemistry
Rights
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
Metadata
Show full item recordAbstract
This thesis describes the development of libraries inspired by the natural product sparteine. Multi-gram synthesis of important intermediate representing sparteine core has been carried out. A scalable process has been developed based on the previously reported total synthesis of (+)-sparteine from Aubé's group. Libraries were produced via parallel synthesis and submitted to NIH Molecular Libraries-Small Molecule Repository for biological screening.
Collections
- Medicinal Chemistry Dissertations and Theses [80]
- Theses [3901]
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