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Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
dc.contributor.author | Miyauchi, Kazuhiro | |
dc.contributor.author | Urakami, Teiji | |
dc.contributor.author | Abeta, Hiroyuki | |
dc.contributor.author | Shi, Honglian | |
dc.contributor.author | Noguchi, Noriko | |
dc.contributor.author | Niki, Etsuo | |
dc.date.accessioned | 2012-05-09T15:00:44Z | |
dc.date.available | 2012-05-09T15:00:44Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | Miyauchi K, Urakami T, Abeta H, Shi H, Noguchi N, and Niki E. Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution. Antioxidants & Redox Signaling 1: 547-554; http://online.liebertpub.com/doi/pdfplus/10.1089/ars.1999.1.4-547 | |
dc.identifier.uri | http://hdl.handle.net/1808/9308 | |
dc.description | This is the publisher's version, also available electronically from: http://online.liebertpub.com/doi/pdfplus/10.1089/ars.1999.1.4-547. | |
dc.description.abstract | The activities of pyrroloquinoline quinone (PQQ), a coenzyme of methanol dehydrogenase and amine oxidase, and its reduced form pyrroloquinoline quinol (PQQH2 ) as an antioxidant have been measured in solution. PQQH2 was stable in the absence of oxygen but rapidly auto-oxidized to PQQ in the presence of oxygen in water. PQQH2 was stable in an aprotic solvent such as acetonitrile, even in air. PQQ did not exert appreciable antioxidant activity, whereas PQQH2 exerted higher reactivity than a-tocopherol toward galvinoxyl radical and peroxyl radical. PQQH2 acted as a potent antioxidant against the oxidation of methyl linoleate in acetonitrile induced by azo compound and produced a clear induction period, from which the apparent stoichiometric number was obtained as 1.1. PQQH2 reduced the a-tocopheroxyl radical and spared a-tocopherol in the oxidation of methyl linoleate. These results suggest that PQQH2 may act as a potent antioxidant, particularly in combination with a-tocopherol. Antiox. Redox Signal. 1, 547-554. | |
dc.language.iso | en | |
dc.publisher | Mary Ann Liebert | |
dc.title | Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution | |
dc.type | Article | |
kusw.kuauthor | Shi, Honglian | |
kusw.kudepartment | Pharmacology and Toxicology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1089/ars.1999.1.4-547 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Pharmacy Scholarly Works [299]