A NEW METHODOLOGY FOR IDENTIFYING INTERFACE RESIDUES INVOLVED IN BINDING PROTEIN COMPLEXES
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Fang, Jianwen; Haasl, R. J.; Dong, Yinghua; Lushington, Gerald H. (BIOMED CENTRAL LTD, 2005-11-23)Background: The development of high-throughput technologies such as yeast two- hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction ( PPI) datasets. Mining ...
Chen, Xue-wen; Liu, Mei; Ward, Robert (Public Library of Science, 2008-02-06)Background As we move into the post genome-sequencing era, an immediate challenge is how to make best use of the large amount of high-throughput experimental data to assign functions to currently uncharacterized proteins. ...
Development of Novel Fluorescence and NMR Reagents for Monitoring Protein-Protein Interactions Between Survivin and Its Protein Binding Partners Bishop, Stephanie Cara (University of Kansas, 2015-08-31)Inhibition of protein-protein interactions is a promising therapeutic strategy for targeting non-enzymatic proteins. One strategy to inhibit protein-protein interactions is to design inhibitors specifically toward the ...