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dc.contributor.advisorHanson, Paul R.
dc.contributor.authorLong, Toby R.
dc.date.accessioned2011-12-02T20:33:57Z
dc.date.available2011-12-02T20:33:57Z
dc.date.issued2010-04-28
dc.date.submitted2010
dc.identifier.otherhttp://dissertations.umi.com/ku:10921
dc.identifier.urihttp://hdl.handle.net/1808/8551
dc.description.abstractThe use of ring-opening metathesis polymerization (ROMP) for polymer-assisted solution phase (PASP) synthesis is described herein. Multiple ROMP-based strategies will be discussed in the scope of this dissertation. These include the development and application of a multifaceted oligomeric phosphate as a facilitated leaving group in both SN2 and SN2´ processes, as well as an in-situ generated sequestration reagent. We also investigate the use of ROMP in an atom-economical approach to generate a diverse collection of cyclic sulfonamides (sultams) whereby a vanishing support protocol imparts a traceless, chromatography-free synthesis of these motifs. Also highlighted within is the ability to use ROMP technology to aid in the development of higher-loading magnetic nanoparticles for the purpose of supported catalysis. These cobalt-based ROMPgel nanoparticles were subsequently doped with Pd and demonstrated for use in several Suzuki-Miyaura coupling reactions. The nanoparticles were conveniently reclaimed via external magnetic field and recycled for later use. Lastly, we present the design, validation, and completion of a 225-member library of thiadiazepin-1,1-dioxide-4-ones using both solution- and polymer-assisted solution phase protocols. The library was validated and conducted on an automated parallel synthesis platform in which a facile, two-step diversity-rendering sequence was performed.
dc.format.extent349 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectOrganic chemistry
dc.subjectPolymer chemistry
dc.subjectInorganic chemistry
dc.subjectChemspeed
dc.subjectMetathesis
dc.subjectNanoparticles
dc.subjectRomp
dc.subjectSultams
dc.titleROMP-Facilitated Methodologies and Automated Library Development of Thiadiazepin-1,1-dioxide-4-ones
dc.typeDissertation
dc.contributor.cmtememberRubin, Michael
dc.contributor.cmtememberMure, Minae
dc.contributor.cmtememberMalinakova, Helena C.
dc.contributor.cmtememberAube, Jeffrey
dc.thesis.degreeDisciplineChemistry
dc.thesis.degreeLevelPh.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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