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dc.contributor.advisorChertoff, Mark Een_US
dc.contributor.authorEarl, Brian Richard
dc.date.accessioned2011-07-04T17:14:25Z
dc.date.available2011-07-04T17:14:25Z
dc.date.issued2010-09-10en_US
dc.date.submitted2010en_US
dc.identifier.otherhttp://dissertations.umi.com/ku:11145en_US
dc.identifier.urihttp://hdl.handle.net/1808/7715en_US
dc.description.abstractA critical barrier to future implementation of regenerative treatments for sensorineural hearing loss is the lack of diagnostic tools that can specify the target(s) within the cochlea and auditory nerve for delivery of therapeutic agents. This study used a gerbil model to test the idea of mapping auditory nerve firing density by tracking the amplitude of high-level compound action potentials (CAPs) while varying the bandwidth of simultaneous masking noise. The distributions of neural firing, obtained by calculating the derivative of the equation describing CAP amplitude growth as a function of distance along the cochlea, indicated that high-level chirp stimuli trigger widespread neural firing along the cochlea that is unaltered by sensory outer hair cell pathology. These results suggest that CAP-derived neural density functions for high-level chirp stimuli may provide reliable maps of auditory nerve density in impaired ears.
dc.format.extent83 pagesen_US
dc.language.isoen_USen_US
dc.publisherUniversity of Kansasen_US
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.en_US
dc.subjectAudiology
dc.subjectPhysiology
dc.subjectAuditory nerve
dc.subjectChirp stimulus
dc.subjectCompound action potential
dc.subjectMasking
dc.titleMapping Auditory Nerve Firing Density using the Compound Action Potential and High-pass Noise Masking
dc.typeDissertationen_US
dc.contributor.cmtememberFerraro, John A
dc.contributor.cmtememberWiden, Judith E
dc.contributor.cmtememberJohnson, Tiffany A
dc.contributor.cmtememberImig, Thomas J
dc.thesis.degreeDisciplineIntercampus Program in Communicative Disorders
dc.thesis.degreeLevelPh.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccessen_US


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