ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Phosphatidylinositol-3 kinase/AKT and Fos like protein 1 regulation of trophoblast differentiation
dc.contributor.advisor | Soares, Michael J. | en_US |
dc.contributor.author | Kent, Lindsey N. | |
dc.date.accessioned | 2011-04-26T03:24:12Z | |
dc.date.available | 2011-04-26T03:24:12Z | |
dc.date.issued | 2010-09-02 | en_US |
dc.date.submitted | 2010 | en_US |
dc.identifier.other | http://dissertations.umi.com/ku:11140 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/7433 | en_US |
dc.description.abstract | Trophoblast cells are one of the earliest lineages to develop in the mammalian embryo. Trophoblast giant cells are the first trophoblast lineage to differentiate and have endocrine and invasive properties. This study focus on the role of the PI3K/AKT signaling pathway in trophoblast giant cell gene expression, steroidogenic potential and invasiveness. Gene profiling of trophoblast populations in the stem, differentiated or differentiated with modified PI3K/AKT signaling states identify genes regulated by PI3K/AKT. These genes are involved in the endocrine and invasive functions of trophoblast and most are upregulated during trophoblast differentiation. Further analysis shows that modification of the PI3K/AKT singling pathway decreases the invasive phenotype of trophoblast and expression of Fos like antigen 1 (FOSL1 or FRA1) a key transcriptional regulator of trophoblast invasion related genes. In summary, we show that FRA1 is a mediator of the PI3K/AKT signaling pathway in regulating gene expression and trophoblast invasion. | |
dc.format.extent | 311 pages | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | University of Kansas | en_US |
dc.rights | This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author. | en_US |
dc.subject | Developmental biology | |
dc.subject | Endocrinology | |
dc.subject | Molecular biology | |
dc.subject | Akt | |
dc.subject | Fra1 | |
dc.subject | Invasion | |
dc.subject | Pi3k | |
dc.subject | Placenta | |
dc.subject | Trophoblast | |
dc.title | Phosphatidylinositol-3 kinase/AKT and Fos like protein 1 regulation of trophoblast differentiation | |
dc.type | Dissertation | en_US |
dc.contributor.cmtemember | Li, Linheng | |
dc.contributor.cmtemember | Petroff, Margaret G. | |
dc.contributor.cmtemember | Vivian, Jay L. | |
dc.contributor.cmtemember | Wolfe, Michael W. | |
dc.thesis.degreeDiscipline | Pathology & Laboratory Medicine | |
dc.thesis.degreeLevel | Ph.D. | |
kusw.oastatus | na | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
kusw.bibid | 8085570 | |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
-
Dissertations [4889]
-
KU Med Center Dissertations and Theses [464]