dc.contributor.advisor | Ward, Robert E | |
dc.contributor.author | Wang, Xiaochen | |
dc.date.accessioned | 2010-07-25T21:42:35Z | |
dc.date.available | 2010-07-25T21:42:35Z | |
dc.date.issued | 2010-04-26 | |
dc.date.submitted | 2010 | |
dc.identifier.other | http://dissertations.umi.com/ku:10868 | |
dc.identifier.uri | http://hdl.handle.net/1808/6402 | |
dc.description.abstract | Development of Drosophila leg imaginal discs provides an ideal model to study hormone-regulated morphogenesis. During the onset of metamorphosis, a pulse of ecdysone triggers the rapid transformation of flat leg imaginal discs into rudimentary adult fly legs. The ecdysone-inducible early gene broad (br), is required for this morphogenesis. The Rho1 signaling pathway interacts with br and plays a central role in imaginal discs morphogenesis. Several unknown Enhancer of br or E(br) alleles that showed interactions with both br and Rho1 pathway genes were isolated. My first project was to characterize E(br)165, which I determined was a mutation in Sec61α. Sec61α specifically perturbs dorsal closure during embryogenesis by attenuating Decapentaplegic (Dpp) signaling. My second project was to identify and characterize genes that are regulated by ecdysone and br at the onset of metamorphosis in leg discs. The results suggest that br may function in concert with ecdysone to regulate leg morphogenesis. | |
dc.format.extent | 120 pages | |
dc.language.iso | EN | |
dc.publisher | University of Kansas | |
dc.rights | This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author. | |
dc.subject | Biology | |
dc.subject | Genetics | |
dc.subject | Developmental biology | |
dc.subject | Cell biology | |
dc.title | Forward and reverse genetic approaches to identify genes involved in leg morphogenesis in Drosophila | |
dc.type | Dissertation | |
dc.contributor.cmtemember | Cohen, Robert | |
dc.contributor.cmtemember | Corbin, Victoria L. | |
dc.contributor.cmtemember | Lundquist, Erik A. | |
dc.contributor.cmtemember | Neufeld, Kristi L. | |
dc.contributor.cmtemember | Ward, Joy | |
dc.thesis.degreeDiscipline | Molecular Biosciences | |
dc.thesis.degreeLevel | Ph.D. | |
kusw.oastatus | na | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
kusw.bibid | 8085496 | |
dc.rights.accessrights | openAccess | |