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dc.contributor.advisorWard, Robert E
dc.contributor.authorWang, Xiaochen
dc.date.accessioned2010-07-25T21:42:35Z
dc.date.available2010-07-25T21:42:35Z
dc.date.issued2010-04-26
dc.date.submitted2010
dc.identifier.otherhttp://dissertations.umi.com/ku:10868
dc.identifier.urihttp://hdl.handle.net/1808/6402
dc.description.abstractDevelopment of Drosophila leg imaginal discs provides an ideal model to study hormone-regulated morphogenesis. During the onset of metamorphosis, a pulse of ecdysone triggers the rapid transformation of flat leg imaginal discs into rudimentary adult fly legs. The ecdysone-inducible early gene broad (br), is required for this morphogenesis. The Rho1 signaling pathway interacts with br and plays a central role in imaginal discs morphogenesis. Several unknown Enhancer of br or E(br) alleles that showed interactions with both br and Rho1 pathway genes were isolated. My first project was to characterize E(br)165, which I determined was a mutation in Sec61α. Sec61α specifically perturbs dorsal closure during embryogenesis by attenuating Decapentaplegic (Dpp) signaling. My second project was to identify and characterize genes that are regulated by ecdysone and br at the onset of metamorphosis in leg discs. The results suggest that br may function in concert with ecdysone to regulate leg morphogenesis.
dc.format.extent120 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectBiology
dc.subjectGenetics
dc.subjectDevelopmental biology
dc.subjectCell biology
dc.titleForward and reverse genetic approaches to identify genes involved in leg morphogenesis in Drosophila
dc.typeDissertation
dc.contributor.cmtememberCohen, Robert
dc.contributor.cmtememberCorbin, Victoria L.
dc.contributor.cmtememberLundquist, Erik A.
dc.contributor.cmtememberNeufeld, Kristi L.
dc.contributor.cmtememberWard, Joy
dc.thesis.degreeDisciplineMolecular Biosciences
dc.thesis.degreeLevelPh.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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