Viagra and other erectile-dysfunction (ED) medications are typically associated with older men. There is thus little research on their use in college-age men. The purpose of the present study was to explore the use of sexual-enhancement drugs (SEDs) in college men and to compare the men who had used SEDs to those who had not used them. Eighty-two male college students completed a questionnaire that included open-ended questions about their use of SEDs and items assessing their sexual history and motives for having sex. The majority of the 16 men who reported having used SEDs used Viagra, followed by herbal products and Ecstasy. Users of these substances reported having had more sex partners and endorsed enhancing pleasure as being a more important reason for having sex than did those who had not used them. Results suggest that the SED users are more sexually exploratory than the nonusers.