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    Mutation, asexual reproduction and genetic load: A study in three parts

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    Marriage_ku_0099D_10544_DATA_1.pdf (2.025Mb)
    Issue Date
    2009-08-24
    Author
    Marriage, Tara N.
    Publisher
    University of Kansas
    Format
    126 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Ecology & Evolutionary Biology
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    My dissertation addresses mutation and complex mating systems (models of mating systems that include outcrossing, selfing, and asexual reproduction) in three distinct chapters. Chapter 2 discusses the direct estimation of mutation rates for di-nucleotide microsatellite markers in the model genetic organism, Arabidopsis thaliana. Chapter 3 describes an empirical study that estimates quantitative genetic variance components, genetic diversity, and inbreeding depression/inbreeding load for a predominately asexual population of Mimulus guttatus. This study also fits different evolutionary models to the empirical data to determine which model best describes the population. Chapter 4 is a theoretical investigation of the effects asexual reproduction, outcrossing and selfing on the average number of deleterious mutations per gamete and inbreeding load for infinite and finite populations. The study utilizes both Infinite (an infinite number of genetic loci and an infinite population size) and Finite (a small number of genetic loci and a variety of small population sizes) computer simulations. These simulations incorporate different meiotic and mitotic mutation rates, varying degrees of dominance and differing strengths of selection.
    URI
    http://hdl.handle.net/1808/5949
    Collections
    • Dissertations [4050]
    • Ecology and Evolutionary Biology Dissertations and Theses [195]

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    785-864-8983

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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