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    Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate

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    Relative Bioavailability_Hanzlik_2.pdf (115.1Kb)
    Issue Date
    2005-06
    Author
    Hanzlik, Robert P.
    Fowler, Stephen C.
    Fisher, D. H.
    Publisher
    American Society for Pharmacology and Experimental Therapeutics
    Type
    Article
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    Abstract
    Published Abstract: Calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. The objective of this study was to compare the oral bioavailability of calcium from calcium formate, a new experimental dietary calcium supplement, to that of calcium citrate and calcium carbonate. In a four-way crossover study, either a placebo or 1200 mg of calcium as calcium carbonate, calcium citrate, or calcium formate were administered orally to 14 healthy adult female volunteers who had fasted overnight. After calcium carbonate, the maximum rise in serum calcium (~4%) and the fall in serum intact para-thyroid hormone 1–84 (iPTH) (~20–40%) did not differ significantly from placebo. After calcium citrate, the changes were modestly but significantly (p < 0.05) greater, but only at 135 to 270 min after ingestion. In contrast, within 60 min after calcium formate serum calcium rose by approximately 15% and serum iPTH fell by 70%. The mean increment in area under the plasma concentration-time curve (0–270 min) for serum calcium after calcium formate (378 mg∙min/dl) was double that for calcium citrate (178 mg∙min/dl; p < 0.01), whereas the latter was only modestly greater than either placebo (107; p < 0.05) or calcium carbonate (91; p < 0.05). In this study, calcium formate was clearly superior to both calcium carbonate and calcium citrate in ability to deliver calcium to the bloodstream after oral administration. Calcium formate may offer significant advantages as a dietary calcium supplement.
    Description
    Final publisher version is available online openly at: http://jpet.aspetjournals.org/content/313/3/1217.full.pdf Author accepted manuscript is available in compliance with NIH requirements at, http://jpet.aspetjournals.org/content/early/2005/02/25/jpet.104.081893/. Abstract is posted in fulfillment of the KU faculty's Open Access policy.
    URI
    http://hdl.handle.net/1808/5936
    Collections
    • Distinguished Professors Scholarly Works [918]
    • Medicinal Chemistry Scholarly Works [255]
    Citation
    Hanzlik RP, Fowler SC, Fisher DH. Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate. J Pharmacol Exp Ther. 2005 Jun; 313(3):1217-22.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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