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Dopaquinone as a Common Intermediate in the Biogenesis of Tyrosine-Derived Quinone Cofactors
dc.contributor.advisor | Mure, Minae | |
dc.contributor.author | Moore, Robyn Haley | |
dc.date.accessioned | 2009-11-02T19:05:24Z | |
dc.date.available | 2009-11-02T19:05:24Z | |
dc.date.issued | 2009-06-16 | |
dc.date.submitted | 2009 | |
dc.identifier.other | http://dissertations.umi.com/ku:10438 | |
dc.identifier.uri | http://hdl.handle.net/1808/5568 | |
dc.description.abstract | Copper amine oxidases (CAOs) are essential for maintaining the level of biogenic amines in the body as well as being involved in the inflammation and immune responses. Lysyl oxidase (LOX), a member of CAO, plays an important role in stabilizing the extracellular matrix but its over-expression has been associated with metastasis/invasion of breast cancer cells. The biogeneses of the topaquinone (TPQ) cofactor of CAO and the lysine tyrosylquinone (LTQ) cofactor in LOX from the corresponding Tyr residue are self-catalyzed processes requiring copper and O2. In CAO, a putative dopaquinone (DPQ) intermediate has been proposed to react with a copper-associated water molecule, through a 1,4-addition mechanism, leading to the formation of TPQ. The D298K mutant of a bacterial CAO produces an iminoquinone tautomer (LTI) of lysine tyrosylquinone (LTQ). The results of this study strongly support the proposal that DPQ is a common intermediate in the biogenesis of these tyrosine-derived cofactors. | |
dc.format.extent | 152 pages | |
dc.language.iso | EN | |
dc.publisher | University of Kansas | |
dc.rights | This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author. | |
dc.subject | Organic chemistry | |
dc.subject | Ltq | |
dc.subject | Quinone cofactor | |
dc.subject | Tpq | |
dc.title | Dopaquinone as a Common Intermediate in the Biogenesis of Tyrosine-Derived Quinone Cofactors | |
dc.type | Dissertation | |
dc.contributor.cmtemember | Schowen, Richard L. | |
dc.contributor.cmtemember | Givens, Richard S | |
dc.contributor.cmtemember | Hanson, Paul R. | |
dc.contributor.cmtemember | Scott, Emily E. | |
dc.thesis.degreeDiscipline | Chemistry | |
dc.thesis.degreeLevel | Ph.D. | |
kusw.oastatus | na | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
kusw.bibid | 7078957 | |
dc.rights.accessrights | openAccess |
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Chemistry Dissertations and Theses [335]
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Dissertations [4889]