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    Novel Effector Protein Secretion and Transcriptional Regulation of the Type Three Secretion System in Chlamydia trachomatis.

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    Spedding_ku_0099M_10361_DATA_1.pdf (9.054Mb)
    Issue Date
    2009-04-29
    Author
    Spedding, Lindsey
    Publisher
    University of Kansas
    Format
    116 pages
    Type
    Thesis
    Degree Level
    M.A.
    Discipline
    Molecular Biosciences
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Chlamydia trachomatis is an obligate intracellular bacterial pathogen with a significant public health impact. A unifying characteristic of Chlamydia is the biphasic developmental cycle that is intimately linked to pathogenesis. Due to its intracellular lifestyle within a membrane bound vacuole, Chlamydia requires a mechanism to interact with and manipulate the host. To facilitate this interaction, C. trachomatis encodes a Type III Secretion System (T3SS) that is likely requisite for chlamydial growth and integral to the developmental cycle. Additionally, little is known about the mechanisms that regulate the developmental cycle, and the T3SS. This thesis is focused on a translocated T3SS effector protein, CT667, that may serve in manipulation of the host, and the role of a transcriptional factor, ChxR, involved in regulating T3SS expression.
    URI
    http://hdl.handle.net/1808/5457
    Collections
    • Theses [3710]
    • Molecular Biosciences Dissertations and Theses [182]
    • Molecular Biosciences Dissertations and Theses [182]

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    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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