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dc.contributor.advisorBerkland, Cory
dc.contributor.authorPlumley, Carl Joseph
dc.date.accessioned2009-02-02T06:04:06Z
dc.date.available2009-02-02T06:04:06Z
dc.date.issued2008-08-05
dc.date.submitted2008
dc.identifier.otherhttp://dissertations2.umi.com/ku:2697
dc.identifier.urihttp://hdl.handle.net/1808/4343
dc.description.abstractEfficient administration of poorly water soluble drugs represents a leading challenge in pulmonary medicine. This route of administration has been used for steroidal treatments for some time, but with room for advancement. New inhalable medicines require a more reliable and effective dosing regimen due to narrow therapeutic indices, and specific and enhanced deposition in the lungs is also desired. This thesis investigates a general method for producing micron sized dry powders for a general class of drugs, poorly water soluble small molecule drugs, for their use in pulmonary drug delivery. Formulation methods already exist for inhalable aerosols, but the resulting powders often show limited deposition efficiency in the deep lung. In this body of work, an alternative formulation strategy is provided for inhalable dry powders using nanoparticle agglomeration that results in a potentially more efficient line of therapy. The model drug used in this study was nifedipine, a well known calcium channel blocker used to treat various symptoms of hypertension. The results indicated that nanoparticle agglomeration is a viable means of creating dry powders with suitable characteristics for pulmonary drug delivery as an alternative to more expensive and less controllable formulation strategies.
dc.format.extent90 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectChemical engineering
dc.subjectPharmaceutical chemistry
dc.subjectNanoparticles
dc.subjectDrug delivery
dc.subjectNifedipine
dc.subjectPulmonary
dc.subjectMedicine
dc.titleNanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery
dc.typeDissertation
dc.contributor.cmtememberGehrke, Stevin
dc.contributor.cmtememberGuzman, Javier
dc.thesis.degreeDisciplineChemical & Petroleum Engineering
dc.thesis.degreeLevelEd.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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