BODY WEIGHT AND COGNITIVE DECLINE IN MCI

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Issue Date
2008-08-08Author
Cronk, Benjamin B.
Publisher
University of Kansas
Format
21 pages
Type
Thesis
Degree Level
M.S.
Discipline
Preventive Medicine and Public Health
Rights
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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Show full item recordAbstract
Abstract Objective: To examine body mass index (BMI) and cognitive decline in subjects diagnosed with mild cognitive impairment (MCI). Methods: Neuropsychological testing was conducted of 286 MCI subjects. General estimating equations (GEE) assessed the relationships of baseline BMI with one-year change in global cognition. Logistic GEE assessed the relationship of BMI with a clinically significant decline in assessments of global cognition and conversion to Alzheimer's disease (AD). Results: Baseline BMI was associated with a significant decline in cognitive performance in MCI. We observed that a low baseline BMI as associated with an increased risk of a clinically significant decline in global cognition. No association between baseline BMI and conversion to AD was observed. Conclusions: Lower BMI is associated with a more rapid decline in cognition in MCI. This relationship suggests changes in metabolism are present in MCI or body composition may influence the rate of cognitive decline in MCI.
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- KU Med Center Dissertations and Theses [464]
- Theses [3901]
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