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    CONTRIBUTIONS OF THE 3' HOX GENES, HOXA1, HOXB1, AND HOXB2, TO PATTERNING OF THE AXIAL SKELETON DURING DEVELOPMENT

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    Issue Date
    2008-08-06
    Author
    Buckley, Rachel
    Publisher
    University of Kansas
    Format
    292 pages
    Type
    Dissertation
    Degree Level
    PH.D.
    Discipline
    Anatomy & Cell Biology
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    To investigate whether Hoxb1, as well as related proteins Hoxa1 and Hoxb2, are involved in vertebral development, we analyzed the skeletons of 18.5dpc Hoxa1, Hoxb1, and Hoxb2 loss-of-function single and double mutant embryos. Our analysis reveals that loss of Hoxb1 and Hoxb2 function leads to multiple homeotic transformations along the vertebral column. The dosages of both HoxB genes seem to be important, since the homeotic transformations significantly increase in penetrance in Hoxb1/Hoxb2 trans-heterozygotes, compared to single heterozygotes. Through the use of transgenic mouse strains, we were also able to reproduce similar transformations upon addition of extra HoxB gene copies. Interestingly, the defects observed in these loss-of-function mutants and transgenic mice occur at the boundaries between morphologically distinct vertebral domains. In conclusion, these data show that the anterior HoxB genes, particularly, Hoxb1 and Hoxb2, play a critical role in patterning the paraxial mesoderm that will give rise to the axial skeleton.
    URI
    http://hdl.handle.net/1808/4236
    Collections
    • Dissertations [4475]
    • KU Med Center Dissertations and Theses [464]

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    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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