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dc.contributor.advisorPetroff, Margaret Gen_US
dc.contributor.authorTaglauer, Elizabeth Susan
dc.date.accessioned2008-09-29T04:57:10Z
dc.date.available2008-09-29T04:57:10Z
dc.date.issued2008-08-08en_US
dc.date.submitted2008en_US
dc.identifier.otherhttp://dissertations2.umi.com/ku:2642en_US
dc.identifier.urihttp://hdl.handle.net/1808/4231en_US
dc.description.abstractDuring pregnancy, the maternal immune system must be carefully modulated as the fetus is immunologically foreign to her leukocytes. We propose that the CD28 family immune receptor, PD-1, functions during pregnancy to control maternal immune reactions. PD-1 is expressed on T lymphocytes and following interaction with its ligand, B7-H1, prevents T cell activation. B7-H1 is expressed in the human placenta throughout gestation, therefore we studied the role of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 inhibits the inflammatory cytokine production of activated decidual T lymphocytes. In addition, possibly through B7-H1:PD-1 interactions, trophoblasts induce regulatory T cell expansion in vitro. Finally, in murine pregnancy, PD-1 controls the accumulation of paternal antigen-specific T cells in the uterus-draining lymph nodes. Overall, these studies suggest that the PD-1:B7-H1 pathway functions to help maintain maternal-fetal tolerance.
dc.format.extent167 pagesen_US
dc.language.isoen_USen_US
dc.publisherUniversity of Kansasen_US
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.en_US
dc.subjectCell biology
dc.subjectPregnancy
dc.subjectImmunology
dc.subjectReproduction
dc.subjectT cells
dc.subjectPd-1
dc.subjectB7-h1
dc.titleThe Role of the PD-1 Immunoreceptor in Pregnancy
dc.typeDissertationen_US
dc.contributor.cmtememberKinsey, William H
dc.contributor.cmtememberRoby, Katherine F
dc.contributor.cmtememberSoares, Michael J
dc.contributor.cmtememberFields, Patrick E
dc.thesis.degreeDisciplineAnatomy & Cell Biology
dc.thesis.degreeLevelPH.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
kusw.bibid6857198
dc.rights.accessrightsopenAccessen_US


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