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    EFFECT OF DIETARY CHOLESTEROL ON BRAIN CHOLESTEROL IN DEVELOPING RATS

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    Issue Date
    2008-04-29
    Author
    Gottipati, Bhavana Sindhu
    Publisher
    University of Kansas
    Format
    68 pages
    Type
    Thesis
    Degree Level
    M.S.
    Discipline
    Dietetics & Nutrition
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Cholesterol is a significant component of brain and is found in both neuronal membranes and myelin. All mammalian milks provide cholesterol during periods of maximal brain growth and myelination. However, infant formulas contain only traces of cholesterol. The purpose of this study is to determine if dietary cholesterol alters rat brain composition during development. Pregnant Long-Evans rats were randomly assigned (12/group) to a semi-synthetic diet with or without cholesterol. On postnatal day 1(P1), litters were culled to eight and weaned on P17. Litters received the same concentration of cholesterol as their dam from P17 to P32. On P32, pups were sacrificed. The left brain cortices were analyzed for cholesterol and protein concentration. Developing rats exposed to the cholesterol diet had an increase in left brain cortex size (p=0.003), cholesterol (p=0.006) and protein concentration (p=0.0005). Exposure to exogenous cholesterol increased brain cholesterol and protein concentration in developing rats.
    URI
    http://hdl.handle.net/1808/3986
    Collections
    • Education Dissertations and Theses [1068]
    • Theses [3797]

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    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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