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Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy
dc.contributor.author | Wang, Mingyang | |
dc.contributor.author | Singh, Rohit | |
dc.contributor.author | Zhang, Wei | |
dc.contributor.author | Orringer, Jeffrey S. | |
dc.contributor.author | Paulus, Yannis M. | |
dc.contributor.author | Yang, Xinmai | |
dc.contributor.author | Wang, Xueding | |
dc.date.accessioned | 2024-06-11T19:20:52Z | |
dc.date.available | 2024-06-11T19:20:52Z | |
dc.date.issued | 2023-09-22 | |
dc.identifier.citation | Wang M, Singh R, Zhang W, Orringer JS, Paulus YM, Yang X, Wang X. Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy. JID Innov. 2023 Sep 22;3(6):100237. doi: 10.1016/j.xjidi.2023.100237. PMID: 38024557; PMCID: PMC10661455 | en_US |
dc.identifier.uri | https://hdl.handle.net/1808/35125 | |
dc.description.abstract | Photo-mediated ultrasound therapy (PUT) is a cavitation-based, highly selective antivascular technique. In this study, the effectiveness and safety of PUT on cutaneous vascular malformation was examined through in vivo experiments in a clinically relevant chicken wattle model, whose microanatomy is similar to that of port-wine stain and other hypervascular dermal diseases in humans. Assessed by optical coherence tomography angiography, the blood vessel density in the chicken wattle decreased by 73.23% after one session of PUT treatment in which 0.707 J/cm2 fluence laser pulses were applied concurrently with ultrasound bursts (n = 7, P < .01). The effectiveness of removing blood vessels in the skin at depth up to 1 mm was further assessed by H&E-stained histology at multiple time points, which included days 1, 3, 7, 14, and 21 after treatment. Additional immunohistochemical analyses with CD31, caspase-3, and Masson’s trichrome stains were performed on day 3 after treatment. The results show that the PUT-induced therapeutic effect was confined and specific to blood vessels only, whereas unwanted collateral damage in other skin tissues such as collagen was avoided. The findings from this study demonstrate that PUT can efficiently and safely remove hypervascular dermal capillaries using laser fluence at a level that is orders of magnitude smaller than that used in conventional laser treatment of vascular lesions, thus offering a safer alternative technique for clinical management of cutaneous vascular malformations. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2023 The Authors This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights.uri | https://www.ncbi.nlm.nih.gov/pmc/about/copyright/ | en_US |
dc.title | Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Singh, Rohit | |
kusw.kudepartment | Institute for Bioengineering Research | en_US |
kusw.kudepartment | Department of Mechanical Engineering | en_US |
dc.identifier.doi | 10.1016/j.xjidi.2023.100237 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC10661455 | en_US |
dc.rights.accessrights | openAccess | en_US |