The Effects of Life Cycle Therapeutic Dosage Administration of Drugs to Albino Rats

Abstract

In the investigations to be presented herein, dosages comparable to human usage have been administered orally to normal animals which have been kept, as far as possible in a constant normal environment with respect to food, housing, temperature, ventilation and general care. The test and control animals have been under almost constant observation throughout the life cycle. An exhaustive study of the literature reveals no precedent for this type of investigation. Sollman et. al. have studied the effects of various alcohols for an average of twenty weeks, and growth curves for white rats are presented by the authors for sixty weeks. Mothing bas been found, however, which presents life cycle changes even for normal untreated animals.