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Covalent Tethers for Precise Amino Alcohol Syntheses: Ring Opening of Epoxides by Pendant Sulfamates and Sulfamides

dc.contributor.authorNagamalla, Someshwar
dc.contributor.authorMague, Joel T.
dc.contributor.authorSathyamoorthi, Shyam
dc.date.accessioned2023-06-13T20:54:06Z
dc.date.available2023-06-13T20:54:06Z
dc.date.issued2023-02-06
dc.identifier.citationNagamalla, S., Mague, J. T., & Sathyamoorthi, S. (2023). Covalent Tethers for Precise Amino Alcohol Syntheses: Ring Opening of Epoxides by Pendant Sulfamates and Sulfamides. Organic letters, 25(6), 982–986. https://doi.org/10.1021/acs.orglett.3c00053en_US
dc.identifier.urihttps://hdl.handle.net/1808/34375
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, Copyright © 2023 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.3c00053.en_US
dc.description.abstractWe describe the development of the first ring opening of epoxides using pendant sulfamates and sulfamides. These reactions are promoted by a base and proceed under mild conditions to afford oxathiazinanes and cyclic sulfamides with excellent diastereoselectivity and regiocontrol. The reactions scale well, and the products serve as synthons for ring-opening reactions.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsCopyright © 2023 American Chemical Societyen_US
dc.subjectCyclizationen_US
dc.subjectEthersen_US
dc.subjectMixturesen_US
dc.subjectRing opening reactionsen_US
dc.subjectSubstitution reactionsen_US
dc.titleCovalent Tethers for Precise Amino Alcohol Syntheses: Ring Opening of Epoxides by Pendant Sulfamates and Sulfamidesen_US
dc.typeArticleen_US
kusw.kuauthorNagamalla, Someshwar
kusw.kuauthorSathyamoorthi, Shyam
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1021/acs.orglett.3c00053en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4705-7349en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC10017054en_US
dc.rights.accessrightsembargoedAccessen_US


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