ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Protein Structure & X-Ray Crystallography Laboratory Scholarly Works

Browse by

 

 

Recent Submissions

  • Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain 

    Rodnin, Mykola V.; Vasques-Montes, Victor; Kyrychenko, Alexander; Oliveira, Nuno F. B.; Kashipathy, Maithri M.; Battaile, Kevin P.; Douglas, Justin; Lovell, Scott; Machuqueiro, Miguel; Ladokhin, Alexey S. (MDPI, 2023-06-25)
    Protonation of key histidine residues has been long implicated in the acid-mediated cellular action of the diphtheria toxin translocation (T-) domain, responsible for the delivery of the catalytic domain into the cell. ...

  • An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression 

    Indeglia, Alexandra; Leung, Jessica C.; Miller, Sven A.; Leu, Julia I-Ju; Dougherty, James F.; Clarke, Nicole L.; Kirven, Nicole A.; Shao, Chunlei; Ke, Lei; Lovell, Scott; Barnoud, Thibaut; Lu, David Y.; Lin, Cindy; Kannan, Toshitha; Battaile, Kevin P.; Yang, Tyler Hong Loong; Oliva, Isabela Batista; Claiborne, Daniel T.; Vogel, Peter; Liu, Lijun; Liu, Qin; Nefedova, Yulia; Cassel, Joel; Auslander, Noam; Kossenkov, Andrew V.; Karanicolas, John; Murphy, Maureen E. (American Association for Cancer Research, 2023-07-07)
    TP53 is the most frequently mutated gene in cancer, yet key target genes for p53-mediated tumor suppression remain unidentified. Here, we characterize a rare, African-specific germline variant of TP53 in the DNA-binding ...

  • Pseudomonas aeruginosa Dps (PA0962) Functions in H2O2 Mediated Oxidative Stress Defense and Exhibits In Vitro DNA Cleaving Activity 

    Rajapaksha, Nimesha; Soldano, Anabel; Yao, Huili; Donnarumma, Fabrizio; Kashipathy, Maithri M.; Seibold, Steve; Battaile, Kevin P.; Lovell, Scott; Rivera, Mario (MDPI, 2023-02-28)
    We report the structural, biochemical, and functional characterization of the product of gene PA0962 from Pseudomonas aeruginosa PAO1. The protein, termed Pa Dps, adopts the Dps subunit fold and oligomerizes into a nearly ...

  • ADAMTSL2 gene variant in patients with features of autosomal dominant connective tissue disorders 

    Steinle, Jacob; Hossain, Waheeda A.; Lovell, Scott; Veatch, Olivia J.; Butler, Merlin G. (Wiley, 2020-12-27)
    Ehlers-Danlos syndrome (EDS) consists of a heterogeneous group of genetically inherited connective tissue disorders. A family with three affected members over two generations with features of Dermatosparaxic EDS (dEDS) ...