dc.contributor.author | La Fountaine, Michael F. | |
dc.contributor.author | Hohn, Asante N. | |
dc.contributor.author | Leahy, Caroline L. | |
dc.contributor.author | Weir, Joseph P. | |
dc.contributor.author | Testa, Anthony J. | |
dc.date.accessioned | 2022-10-26T21:40:49Z | |
dc.date.available | 2022-10-26T21:40:49Z | |
dc.date.issued | 2022-08-05 | |
dc.identifier.citation | La Fountaine, Michael F et al. “Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion.” Frontiers in neurology vol. 13 947524. 5 Aug. 2022, doi:10.3389/fneur.2022.947524 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/33630 | |
dc.description.abstract | Introduction: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion.Methods: A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0–6) for headache, pressure in head, blurred vision, and sensitivity to light/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses.Results: Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (p < 0.001, η2 = 0.404), but the group (p = 0.055) and interaction effects only trended (p = 0.094). Pearson's χ2-tests revealed that 88% of those with return-to play (RTP) exclusions ≥15 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP < 14 day.Conclusion: Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2022 La Fountaine, Hohn, Leahy, Weir and Testa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Mild traumatic brain injury | en_US |
dc.subject | Acute post-traumatic headache | en_US |
dc.subject | Calcitonin gene-related peptide | en_US |
dc.subject | Post-concussion syndrome | en_US |
dc.subject | Genotyping | en_US |
dc.title | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Weir, Joseph P. | |
kusw.kudepartment | Health, Sport and Exercise Sciences | en_US |
kusw.kudepartment | Osness Human Performance Laboratories | en_US |
dc.identifier.doi | 10.3389/fneur.2022.947524 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC9389220 | en_US |
dc.rights.accessrights | openAccess | en_US |