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dc.contributor.authorLa Fountaine, Michael F.
dc.contributor.authorHohn, Asante N.
dc.contributor.authorLeahy, Caroline L.
dc.contributor.authorWeir, Joseph P.
dc.contributor.authorTesta, Anthony J.
dc.date.accessioned2022-10-26T21:40:49Z
dc.date.available2022-10-26T21:40:49Z
dc.date.issued2022-08-05
dc.identifier.citationLa Fountaine, Michael F et al. “Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion.” Frontiers in neurology vol. 13 947524. 5 Aug. 2022, doi:10.3389/fneur.2022.947524en_US
dc.identifier.urihttp://hdl.handle.net/1808/33630
dc.description.abstractIntroduction: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion.

Methods: A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0–6) for headache, pressure in head, blurred vision, and sensitivity to light/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses.

Results: Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (p < 0.001, η2 = 0.404), but the group (p = 0.055) and interaction effects only trended (p = 0.094). Pearson's χ2-tests revealed that 88% of those with return-to play (RTP) exclusions ≥15 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP < 14 day.

Conclusion: Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury.
en_US
dc.publisherPublic Library of Scienceen_US
dc.rights© 2022 La Fountaine, Hohn, Leahy, Weir and Testa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectMild traumatic brain injuryen_US
dc.subjectAcute post-traumatic headacheen_US
dc.subjectCalcitonin gene-related peptideen_US
dc.subjectPost-concussion syndromeen_US
dc.subjectGenotypingen_US
dc.titleObservations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussionen_US
dc.typeArticleen_US
kusw.kuauthorWeir, Joseph P.
kusw.kudepartmentHealth, Sport and Exercise Sciencesen_US
kusw.kudepartmentOsness Human Performance Laboratoriesen_US
dc.identifier.doi10.3389/fneur.2022.947524en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC9389220en_US
dc.rights.accessrightsopenAccessen_US


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© 2022 La Fountaine, Hohn, Leahy, Weir and Testa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as: © 2022 La Fountaine, Hohn, Leahy, Weir and Testa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).