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Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion
La Fountaine, Michael F. Hohn, Asante N. Leahy, Caroline L. Weir, Joseph P. Testa, Anthony J.
La Fountaine, Michael F.
Hohn, Asante N.
Leahy, Caroline L.
Weir, Joseph P.
Testa, Anthony J.
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Abstract
Introduction: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion.
Methods: A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0–6) for headache, pressure in head, blurred vision, and sensitivity to light/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses.
Results: Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (p < 0.001, η2 = 0.404), but the group (p = 0.055) and interaction effects only trended (p = 0.094). Pearson's χ2-tests revealed that 88% of those with return-to play (RTP) exclusions ≥15 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP < 14 day.
Conclusion: Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury.
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Date
2022-08-05
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Public Library of Science
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Keywords
Mild traumatic brain injury, Acute post-traumatic headache, Calcitonin gene-related peptide, Post-concussion syndrome, Genotyping
Citation
La Fountaine, Michael F et al. “Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion.” Frontiers in neurology vol. 13 947524. 5 Aug. 2022, doi:10.3389/fneur.2022.947524